PMID- 24323541
OWN - NLM
STAT- MEDLINE
DCOM- 20150330
LR  - 20220321
IS  - 1522-726X (Electronic)
IS  - 1522-1946 (Linking)
VI  - 84
IP  - 1
DP  - 2014 Jul 1
TI  - Percutaneous edge-to-edge repair of the mitral valve in patients with 
      degenerative versus functional mitral regurgitation.
PG  - 137-46
LID - 10.1002/ccd.25331 [doi]
AB  - OBJECTIVES: To prospectively assess the outcome of percutaneous edge-to-edge 
      repair in patients with degenerative versus functional mitral regurgitation (MR). 
      BACKGROUND: The optimal patient population eligible for percutaneous edge-to-edge 
      repair has yet to be defined. METHODS: We analyzed 119 patients treated by 
      percutaneous edge-to-edge repair for symptomatic MR, 72 patients with 
      degenerative and 47 patients with functional MR. The primary endpoints were 
      defined as procedural success (MR grade reduction >/=1 grade) as well as a 
      composite endpoint defined as freedom from MR 3+ or 4+, mitral valve 
      reintervention and death 12 months after clip implantation. In patients with 
      successful clip placement we further analyzed MR grade, New York Heart 
      Association (NYHA) functional class, distance in the 6 min walking test and left 
      ventricular volumes 12 months after clip implantation. RESULTS: The primary 
      success rate of all intended clipping procedures was 83.3% for degenerative and 
      89.4% for functional MR (P = 0.42). Regarding the composite endpoint we observed 
      an event free survival of 59.7% in patients treated for degenerative MR and 63.8% 
      in patients treated for functional MR (P = 0.73). We observed a highly 
      significant reduction in MR grade as well as improvement in NYHA functional 
      status in both groups 12 months after clip implantation. However, there was a 
      more pronounced MR grade reduction in patients treated for degenerative MR 
      compared with patients treated for functional MR. CONCLUSIONS: Percutaneous 
      edge-to-edge repair of the mitral valve is feasible and comparably effective in 
      patients with degenerative and functional MR.
CI  - (c) 2013 Wiley Periodicals, Inc.
FAU - Braun, Daniel
AU  - Braun D
AD  - Klinik fur Herz- und Kreislauferkrankungen im Erwachsenenalter, Deutsches 
      Herzzentrum, TU Munchen, Munich, Germany; Medizinische Klinik und Poliklinik I, 
      Klinikum der Universitat Munchen, Munich, Germany; Munich Heart Alliance, Munich, 
      Germany.
FAU - Lesevic, Hasema
AU  - Lesevic H
FAU - Orban, Martin
AU  - Orban M
FAU - Michalk, Fabian
AU  - Michalk F
FAU - Barthel, Petra
AU  - Barthel P
FAU - Hoppe, Katharina
AU  - Hoppe K
FAU - Sonne, Carolin
AU  - Sonne C
FAU - Pache, Jurgen
AU  - Pache J
FAU - Mehilli, Julinda
AU  - Mehilli J
FAU - Kastrati, Adnan
AU  - Kastrati A
FAU - Hausleiter, Jorg
AU  - Hausleiter J
FAU - Massberg, Steffen
AU  - Massberg S
LA  - eng
PT  - Journal Article
DEP - 20140106
PL  - United States
TA  - Catheter Cardiovasc Interv
JT  - Catheterization and cardiovascular interventions : official journal of the 
      Society for Cardiac Angiography & Interventions
JID - 100884139
SB  - IM
MH  - Aged
MH  - Cardiac Catheterization
MH  - Echocardiography
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Valve Prosthesis Implantation/*methods
MH  - Humans
MH  - Male
MH  - Mitral Valve/*surgery
MH  - Mitral Valve Insufficiency/physiopathology/*surgery
MH  - Retrospective Studies
MH  - Severity of Illness Index
MH  - Treatment Outcome
MH  - Ventricular Function, Left/*physiology
OTO - NOTNLM
OT  - MitraClip(R)
OT  - degenerative MR
OT  - functional MR
OT  - mitral regurgitation
EDAT- 2013/12/11 06:00
MHDA- 2015/03/31 06:00
CRDT- 2013/12/11 06:00
PHST- 2013/03/25 00:00 [received]
PHST- 2013/10/16 00:00 [revised]
PHST- 2013/11/28 00:00 [accepted]
PHST- 2013/12/11 06:00 [entrez]
PHST- 2013/12/11 06:00 [pubmed]
PHST- 2015/03/31 06:00 [medline]
AID - 10.1002/ccd.25331 [doi]
PST - ppublish
SO  - Catheter Cardiovasc Interv. 2014 Jul 1;84(1):137-46. doi: 10.1002/ccd.25331. Epub 
      2014 Jan 6.