PMID- 24323723
OWN - NLM
STAT- MEDLINE
DCOM- 20141228
LR  - 20211021
IS  - 1868-601X (Electronic)
IS  - 1868-4483 (Print)
IS  - 1868-4483 (Linking)
VI  - 5
IP  - 3
DP  - 2014 Jun
TI  - Vascular neural network phenotypic transformation after traumatic injury: 
      potential role in long-term sequelae.
PG  - 394-406
LID - 10.1007/s12975-013-0304-z [doi]
AB  - The classical neurovascular unit (NVU), composed primarily of endothelium, 
      astrocytes, and neurons, could be expanded to include smooth muscle and 
      perivascular nerves present in both the up- and downstream feeding blood vessels 
      (arteries and veins). The extended NVU, which can be defined as the vascular 
      neural network (VNN), may represent a new physiological unit to consider for 
      therapeutic development in stroke, traumatic brain injury, and other brain 
      disorders (Zhang et al., Nat Rev Neurol 8(12):711-716, 2012). This review is 
      focused on traumatic brain injury and resultant post-traumatic changes in 
      cerebral blood flow, smooth muscle cells, matrix, blood-brain barrier structures 
      and function, and the association of these changes with cognitive outcomes as 
      described in clinical and experimental reports. We suggest that studies 
      characterizing TBI outcomes should increase their focus on changes to the VNN, as 
      this may yield meaningful therapeutic targets to resolve posttraumatic 
      dysfunction.
FAU - Badaut, J
AU  - Badaut J
AD  - Department of Pediatrics, Loma Linda University School of Medicine, Coleman 
      Pavilion, Room A1120, 11175 Campus Street, Loma Linda, CA, 92354, USA, 
      jbadaut@llu.edu.
FAU - Bix, G J
AU  - Bix GJ
LA  - eng
GR  - R01 HD061946/HD/NICHD NIH HHS/United States
GR  - R01HD061946/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20131129
PL  - United States
TA  - Transl Stroke Res
JT  - Translational stroke research
JID - 101517297
SB  - IM
MH  - Animals
MH  - Blood-Brain Barrier/pathology
MH  - Brain/*blood supply/metabolism/*pathology
MH  - Brain Injuries/*complications
MH  - Cerebrovascular Disorders/*etiology
MH  - Humans
MH  - Muscle, Smooth, Vascular/metabolism/pathology
MH  - Myocytes, Smooth Muscle/metabolism/pathology
MH  - Nerve Net/*blood supply/metabolism/*pathology
MH  - Phenotype
MH  - Vascular Remodeling
PMC - PMC4028405
MID - NIHMS545364
COIS- Conflict of Interest: Jerome Badaut and Gregory Bix declare that they have no 
      conflict of interest.
EDAT- 2013/12/11 06:00
MHDA- 2014/12/30 06:00
PMCR- 2015/06/01
CRDT- 2013/12/11 06:00
PHST- 2013/09/04 00:00 [received]
PHST- 2013/10/24 00:00 [accepted]
PHST- 2013/10/23 00:00 [revised]
PHST- 2013/12/11 06:00 [entrez]
PHST- 2013/12/11 06:00 [pubmed]
PHST- 2014/12/30 06:00 [medline]
PHST- 2015/06/01 00:00 [pmc-release]
AID - 10.1007/s12975-013-0304-z [doi]
PST - ppublish
SO  - Transl Stroke Res. 2014 Jun;5(3):394-406. doi: 10.1007/s12975-013-0304-z. Epub 
      2013 Nov 29.