PMID- 24323863
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20131211
LR  - 20211021
IS  - 1868-601X (Electronic)
IS  - 1868-4483 (Print)
IS  - 1868-4483 (Linking)
VI  - 3
IP  - Suppl 1
DP  - 2012 Jul
TI  - Chemokines and their receptors in intracerebral hemorrhage.
PG  - 70-9
LID - 10.1007/s12975-012-0155-z [doi]
AB  - Intracerebral hemorrhage (ICH) is a devastating clinical event which results in a 
      high rate of disability and death. At present, no effective treatment is 
      available for ICH. Accumulating evidence suggests that inflammatory responses 
      contribute significantly to the ICH-induced secondary brain outcomes. During ICH, 
      inflammatory cells accumulate at the ICH site attracted by gradients of 
      chemokines. This review summarizes recent progress in ICH studies and the 
      chemoattractants that act during the injury and focuses on and introduces the 
      basic biology of the chemokine monocyte chemoattractant protein-1 (MCP1) and its 
      role in the progression of ICH. Better understanding of MCP1 signaling cascade 
      and the compensation after its inhibition could shed light on the development of 
      effective treatments for ICH.
FAU - Yao, Yao
AU  - Yao Y
AD  - Program in Molecular and Cellular Pharmacology, Department of Pharmacological 
      Sciences, Stony Brook University, Stony Brook, NY, 11794-8651, USA.
FAU - Tsirka, Stella E
AU  - Tsirka SE
LA  - eng
GR  - R01 NS042168/NS/NINDS NIH HHS/United States
PT  - Journal Article
DEP - 20120403
PL  - United States
TA  - Transl Stroke Res
JT  - Translational stroke research
JID - 101517297
PMC - PMC7453158
MID - NIHMS1559957
EDAT- 2012/07/01 00:00
MHDA- 2012/07/01 00:01
PMCR- 2020/08/28
CRDT- 2013/12/11 06:00
PHST- 2012/02/28 00:00 [received]
PHST- 2012/03/13 00:00 [accepted]
PHST- 2012/03/12 00:00 [revised]
PHST- 2013/12/11 06:00 [entrez]
PHST- 2012/07/01 00:00 [pubmed]
PHST- 2012/07/01 00:01 [medline]
PHST- 2020/08/28 00:00 [pmc-release]
AID - 10.1007/s12975-012-0155-z [doi]
PST - ppublish
SO  - Transl Stroke Res. 2012 Jul;3(Suppl 1):70-9. doi: 10.1007/s12975-012-0155-z. Epub 
      2012 Apr 3.