PMID- 24324515
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20131210
LR  - 20211021
IS  - 1741-427X (Print)
IS  - 1741-4288 (Electronic)
IS  - 1741-427X (Linking)
VI  - 2013
DP  - 2013
TI  - Effect of KIOM-79 on Diabetes-Induced Myocardial Fibrosis in Zucker Diabetic 
      Fatty Rats.
PG  - 547653
LID - 10.1155/2013/547653 [doi]
LID - 547653
AB  - KIOM-79, a herbal mixture of parched Puerariae radix, gingered Magnoliae cortex, 
      Glycyrrhizae radix, and Euphorbiae radix, has a strong inhibitory effect on 
      advanced glycation end products (AGEs) formation. We investigated the beneficial 
      effects of KIOM-79 on cardiac fibrosis in Zucker diabetic fatty (ZDF) rats. 
      KIOM-79 (50 or 500 mg/kg/day) was orally administered for 13 weeks. AGEs 
      formation and collagen expression in the myocardium were assessed by 
      immunohistochemistry. The expression levels of the receptor for AGEs (RAGE), 
      transforming growth factor- beta 1 (TGF- beta 1), collagen IV, fibronectin, urotensin 
      II, and urotensin II receptor were examined in the myocardial tissue of ZDF rats. 
      KIOM-79 treatment at 500 mg/kg inhibited the accumulation of AGEs, reduced RAGE 
      mRNA and protein expression, and reduced the upregulation of cardiac fibrogenic 
      factors, such as fibronectin and collagen IV, in heart of ZDF rats. Additionally, 
      KIOM-79 ameliorated urotensin II/receptor gene expression in the cardiac tissue 
      of ZDF rats. Our findings indicate that KIOM-79 diminishes cardiac fibrosis in 
      ZDF rats by preventing AGEs accumulation and RAGE overexpression and by 
      modulating the cardiac urotensin II/receptor pathway, which decreases the amount 
      of profibrotic factors, such as TGF- beta 1, fibronectin, and collagen in cardiac 
      tissue.
FAU - Kim, Junghyun
AU  - Kim J
AD  - Korean Medicine Based Herbal Drug Development Group, Herbal Medicine Research 
      Division, Korea Institute of Oriental Medicine, 1672 Yuseongdae-ro, Yuseong-gu, 
      Daejeon 305-811, Republic of Korea.
FAU - Sohn, Eunjin
AU  - Sohn E
FAU - Kim, Chan-Sik
AU  - Kim CS
FAU - Lee, Yun Mi
AU  - Lee YM
FAU - Jo, Kyuhyung
AU  - Jo K
FAU - Kim, Jin Sook
AU  - Kim JS
LA  - eng
PT  - Journal Article
DEP - 20131113
PL  - United States
TA  - Evid Based Complement Alternat Med
JT  - Evidence-based complementary and alternative medicine : eCAM
JID - 101215021
PMC - PMC3845371
EDAT- 2013/12/11 06:00
MHDA- 2013/12/11 06:01
PMCR- 2013/11/13
CRDT- 2013/12/11 06:00
PHST- 2013/02/15 00:00 [received]
PHST- 2013/09/25 00:00 [revised]
PHST- 2013/09/29 00:00 [accepted]
PHST- 2013/12/11 06:00 [entrez]
PHST- 2013/12/11 06:00 [pubmed]
PHST- 2013/12/11 06:01 [medline]
PHST- 2013/11/13 00:00 [pmc-release]
AID - 10.1155/2013/547653 [doi]
PST - ppublish
SO  - Evid Based Complement Alternat Med. 2013;2013:547653. doi: 10.1155/2013/547653. 
      Epub 2013 Nov 13.