PMID- 24324571
OWN - NLM
STAT- MEDLINE
DCOM- 20140908
LR  - 20220408
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 8
IP  - 12
DP  - 2013
TI  - Associations between tumor necrosis factor-alpha polymorphisms and risk of psoriasis: 
      a meta-analysis.
PG  - e68827
LID - 10.1371/journal.pone.0068827 [doi]
LID - e68827
AB  - BACKGROUND: Tumor necrosis factor-alpha (TNF-alpha) may play an important role in the 
      recalcitrant inflammatory and hyperproliferative dermatosis of psoriasis, and 
      there may be a relationship between TNF-alpha polymorphisms and psoriasis risk. 
      METHODS: We performed a meta-analysis to evaluate the associations between TNF-alpha 
      polymorphisms and psoriasis. Electronic searches of Pubmed, Embase, and Web of 
      Science were performed for all publications on the associations between TNF-alpha 
      polymorphisms and psoriasis through September 26, 2012. The pooled odds ratios 
      (ORs) with their 95% confidence interval (95%CIs) were calculated to assess the 
      associations. RESULTS: Sixteen case-control studies with a total of 2,253 
      psoriasis cases and 1,947 controls on TNF-alpha 308 G/A polymorphism and fourteen 
      studies on TNF-alpha 238 G/A polymorphism with 2,104 cases and 1,838 controls were 
      finally included into the meta-analysis. Overall, TNF-alpha 308 G/A polymorphism was 
      significantly associated with decreased risk of psoriasis under three genetic 
      comparison models (for A versus G: fixed-effects OR 0.71, 95%CI 0.62-0.82, P < 
      0.001; for AG versus GG: fixed-effects OR 0.67, 95%CI 0.57-0.78, P < 0.001; for 
      AA/AG versus GG: fixed-effects OR 0.67, 95%CI 0.58-0.78, P < 0.001). In addition, 
      TNF-alpha 238 G/A polymorphism was associated with increased risk of psoriasis under 
      three genetic models (for A versus G: fixed-effects OR 2.46, 95%CI 2.04-2.96, P < 
      0.001; for AG versus GG: fixed-effects OR 2.69, 95%CI 2.20-3.28, P < 0.001; for 
      AA/AG versus GG: fixed-effects OR 2.68, 95%CI 2.20-3.26, P < 0.001). Subgroup 
      analysis by ethnicity identified a significant association between TNF-alpha 308 G/A 
      polymorphism and decreased risk of psoriasis in both Caucasians and Asians and a 
      significant association between TNF-alpha 238 G/A polymorphism and increased risk of 
      psoriasis in Caucasians. CONCLUSIONS: The meta-analysis suggests that TNF-alpha 308 
      G/A polymorphism is associated with decreased risk of psoriasis, while TNF-alpha 238 
      G/A is associated with increased risk of psoriasis.
FAU - Zhuang, Le
AU  - Zhuang L
AD  - Department of Dermatology, Qilu Hospital, Shandong University, Jinan, China.
FAU - Ma, Weiyuan
AU  - Ma W
FAU - Cai, Daxing
AU  - Cai D
FAU - Zhong, Hua
AU  - Zhong H
FAU - Sun, Qing
AU  - Sun Q
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20131204
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Case-Control Studies
MH  - Databases, Bibliographic
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Models, Genetic
MH  - Odds Ratio
MH  - *Polymorphism, Single Nucleotide
MH  - Psoriasis/diagnosis/*genetics
MH  - Risk
MH  - Tumor Necrosis Factor-alpha/*genetics
PMC - PMC3850909
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2013/12/11 06:00
MHDA- 2014/09/10 06:00
PMCR- 2013/12/04
CRDT- 2013/12/11 06:00
PHST- 2013/01/21 00:00 [received]
PHST- 2013/06/02 00:00 [accepted]
PHST- 2013/12/11 06:00 [entrez]
PHST- 2013/12/11 06:00 [pubmed]
PHST- 2014/09/10 06:00 [medline]
PHST- 2013/12/04 00:00 [pmc-release]
AID - PONE-D-13-03899 [pii]
AID - 10.1371/journal.pone.0068827 [doi]
PST - epublish
SO  - PLoS One. 2013 Dec 4;8(12):e68827. doi: 10.1371/journal.pone.0068827. eCollection 
      2013.