PMID- 24324648
OWN - NLM
STAT- MEDLINE
DCOM- 20140908
LR  - 20221207
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 8
IP  - 12
DP  - 2013
TI  - Genome-wide association study for levels of total serum IgE identifies HLA-C in a 
      Japanese population.
PG  - e80941
LID - 10.1371/journal.pone.0080941 [doi]
LID - e80941
AB  - Most of the previously reported loci for total immunoglobulin E (IgE) levels are 
      related to Th2 cell-dependent pathways. We undertook a genome-wide association 
      study (GWAS) to identify genetic loci responsible for IgE regulation. A total of 
      479,940 single nucleotide polymorphisms (SNPs) were tested for association with 
      total serum IgE levels in 1180 Japanese adults. Fine-mapping with SNP imputation 
      demonstrated 6 candidate regions: the PYHIN1/IFI16, MHC classes I and II, LEMD2, 
      GRAMD1B, and chr13ratio60576338 regions. Replication of these candidate loci in each 
      region was assessed in 2 independent Japanese cohorts (n = 1110 and 1364, 
      respectively). SNP rs3130941 in the HLA-C region was consistently associated with 
      total IgE levels in 3 independent populations, and the meta-analysis yielded 
      genome-wide significance (P = 1.07x10(-10)). Using our GWAS results, we also 
      assessed the reproducibility of previously reported gene associations with total 
      IgE levels. Nine of 32 candidate genes identified by a literature search were 
      associated with total IgE levels after correction for multiple testing. Our 
      findings demonstrate that SNPs in the HLA-C region are strongly associated with 
      total serum IgE levels in the Japanese population and that some of the previously 
      reported genetic associations are replicated across ethnic groups.
FAU - Yatagai, Yohei
AU  - Yatagai Y
AD  - Department of Pulmonary Medicine, Faculty of Medicine, University of Tsukuba, 
      Ibaraki, Japan.
FAU - Sakamoto, Tohru
AU  - Sakamoto T
FAU - Masuko, Hironori
AU  - Masuko H
FAU - Kaneko, Yoshiko
AU  - Kaneko Y
FAU - Yamada, Hideyasu
AU  - Yamada H
FAU - Iijima, Hiroaki
AU  - Iijima H
FAU - Naito, Takashi
AU  - Naito T
FAU - Noguchi, Emiko
AU  - Noguchi E
FAU - Hirota, Tomomitsu
AU  - Hirota T
FAU - Tamari, Mayumi
AU  - Tamari M
FAU - Imoto, Yoshimasa
AU  - Imoto Y
FAU - Tokunaga, Takahiro
AU  - Tokunaga T
FAU - Fujieda, Shigeharu
AU  - Fujieda S
FAU - Konno, Satoshi
AU  - Konno S
FAU - Nishimura, Masaharu
AU  - Nishimura M
FAU - Hizawa, Nobuyuki
AU  - Hizawa N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131204
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (HLA-C Antigens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Asian People
MH  - Asthma/*genetics/immunology
MH  - Cohort Studies
MH  - Dermatitis, Atopic/*genetics/immunology
MH  - Female
MH  - Gene Expression Regulation
MH  - Genetic Loci
MH  - Genome-Wide Association Study
MH  - HLA-C Antigens/*genetics/immunology
MH  - Humans
MH  - Immunoglobulin E/*genetics/immunology
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Reproducibility of Results
PMC - PMC3851760
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2013/12/11 06:00
MHDA- 2014/09/10 06:00
PMCR- 2013/12/04
CRDT- 2013/12/11 06:00
PHST- 2013/07/16 00:00 [received]
PHST- 2013/10/07 00:00 [accepted]
PHST- 2013/12/11 06:00 [entrez]
PHST- 2013/12/11 06:00 [pubmed]
PHST- 2014/09/10 06:00 [medline]
PHST- 2013/12/04 00:00 [pmc-release]
AID - PONE-D-13-29337 [pii]
AID - 10.1371/journal.pone.0080941 [doi]
PST - epublish
SO  - PLoS One. 2013 Dec 4;8(12):e80941. doi: 10.1371/journal.pone.0080941. eCollection 
      2013.