PMID- 24324974
OWN - NLM
STAT- MEDLINE
DCOM- 20140729
LR  - 20220316
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2013
DP  - 2013
TI  - Chitosan dermal substitute and chitosan skin substitute contribute to accelerated 
      full-thickness wound healing in irradiated rats.
PG  - 795458
LID - 10.1155/2013/795458 [doi]
LID - 795458
AB  - Wounds with full-thickness skin loss are commonly managed by skin grafting. In 
      the absence of a graft, reepithelialization is imperfect and leads to increased 
      scar formation. Biomaterials can alter wound healing so that it produces more 
      regenerative tissue and fewer scars. This current study use the new chitosan 
      based biomaterial in full-thickness wound with impaired healing on rat model. 
      Wounds were evaluated after being treated with a chitosan dermal substitute, a 
      chitosan skin substitute, or duoderm CGF. Wounds treated with the chitosan skin 
      substitute showed the most re-epithelialization (33.2 +/- 2.8%), longest epithelial 
      tongue (1.62 +/- 0.13 mm), and shortest migratory tongue distance (7.11 +/- 0.25 mm). 
      The scar size of wounds treated with the chitosan dermal substitute (0.13 +/- 
      0.02 cm) and chitosan skin substitute (0.16 +/- 0.05 cm) were significantly 
      decreased (P < 0.05) compared with duoderm (0.45 +/- 0.11 cm). Human leukocyte 
      antigen (HLA) expression on days 7, 14, and 21 revealed the presence of human 
      hair follicle stem cells and fibroblasts that were incorporated into and 
      surviving in the irradiated wound. We have proven that a chitosan dermal 
      substitute and chitosan skin substitute are suitable for wound healing in 
      full-thickness wounds that are impaired due to radiation.
FAU - Mohd Hilmi, Abu Bakar
AU  - Mohd Hilmi AB
AD  - Reconstructive Sciences Unit, School of Medical Sciences, Universiti Sains 
      Malaysia, 16150 Kelantan, Malaysia.
FAU - Halim, Ahmad Sukari
AU  - Halim AS
FAU - Jaafar, Hasnan
AU  - Jaafar H
FAU - Asiah, Abu Bakar
AU  - Asiah AB
FAU - Hassan, Asma
AU  - Hassan A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131113
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (Biocompatible Materials)
RN  - 9012-76-4 (Chitosan)
SB  - IM
MH  - Animals
MH  - Biocompatible Materials/chemistry/*therapeutic use
MH  - Chitosan/chemistry/*therapeutic use
MH  - Disease Models, Animal
MH  - Fibroblasts/cytology
MH  - Humans
MH  - Rats
MH  - *Skin Transplantation
MH  - Skin, Artificial
MH  - *Wound Healing
PMC - PMC3845726
EDAT- 2013/12/11 06:00
MHDA- 2014/07/30 06:00
PMCR- 2013/11/13
CRDT- 2013/12/11 06:00
PHST- 2013/07/04 00:00 [received]
PHST- 2013/09/12 00:00 [revised]
PHST- 2013/09/29 00:00 [accepted]
PHST- 2013/12/11 06:00 [entrez]
PHST- 2013/12/11 06:00 [pubmed]
PHST- 2014/07/30 06:00 [medline]
PHST- 2013/11/13 00:00 [pmc-release]
AID - 10.1155/2013/795458 [doi]
PST - ppublish
SO  - Biomed Res Int. 2013;2013:795458. doi: 10.1155/2013/795458. Epub 2013 Nov 13.