PMID- 24325110
OWN - NLM
STAT- MEDLINE
DCOM- 20140829
LR  - 20131211
IS  - 1672-173X (Print)
IS  - 1672-173X (Linking)
VI  - 44
IP  - 5
DP  - 2013 Sep
TI  - [The changes of gastrointestinal hormones GLP-1, PYY and ghrelin in patients with 
      newly diagnosed type 2 diabetes mellitus].
PG  - 774-8
AB  - OBJECTIVE: To study the changes of plasma glucagon-like peptide-1 (GLP-1), serum 
      peptide-YY (PYY) and Ghrelin and their secretion functions in patients with newly 
      diagnosed type 2 diabetes mellitus (T2DM). METHOD: A total of 102 subjects were 
      enrolled, including 32 normal-glucose-tolerance controls (NGT) and 70 patients 
      with newly diagnosed T2DM. Height, body mass, waist circumference (WC) and hip 
      circumference were measured. The plasma lipids and 0 h, 1/2 h, 2 h plasma 
      glucose, insulin (INS), GLP-1, serum PYY and Ghrelin in a standard meal test in 
      each subject were detected, and body mass index (BMI), homeostasis model 
      assessment of insulin resistance (HOMA-IR), insulin sensitivity index (ISI), 
      homeostasis model assessment of beta cell function (HOMA-B) and early insulin 
      secretion function index (DeltaI30/DeltaG30) were calculated. All these variables 
      were compared between the two groups. RESULTS: Compared with those in NGT group, 
      the WC, fasting plasma glucose (FPG), postprandial plasma glucose (2 h-PG), 
      triglyceride (TG), HOMA-IR were significantly higher (P 0.05), while INS(30), 
      HOMA-B, ISI, DeltaI30/DeltaG30 were significantly lower in T2DM group (P<0. 05). 
      In addition, in T2DM group, 0 h, 1/2 h, 2 h plasma GLP-1 and serum PYY and the 
      area under the curve (AUC) of GLP-1 (GLP-lAuc ) and PYY (PYYAc) in standard meal 
      test were significantly lower (P<0. 05), but the serum Ghrelin and GhrelinA, were 
      significantly higher (P<0. 05). Meanwhile, the secretory peak of GLP-1 and PYY 
      after standard meal in T2DM patients all disappeared. In T2DM group, PYYAUC and 
      TG were negatively correlated (P<0.05), the fasting serum Ghrelin level was 
      negatively associated with total cholesterol (TC), and GhrelinAuc was positively 
      associated with HOMA-B, but negatively with the low-density lipoprotein 
      cholesterol (LDL-C) and FPG (P(<0. 05). CONCLUSION: Patients with newly diagnosed 
      T2DM have decreased fasting and postprandial GLP-1 and PYY levels, along with 
      changes of their secretion mode and increased levels of Ghrelin.
FAU - Cui, Tao
AU  - Cui T
AD  - Department of Endocrinology and Metabolism, West China Hospital, Sichuan 
      University, Chengdu 610041, China.
FAU - Ren, Yan
AU  - Ren Y
FAU - Ma, Hong
AU  - Ma H
FAU - Liu, Song-Fang
AU  - Liu SF
FAU - Zhang, Xiang-Xun
AU  - Zhang XX
FAU - Yu, Hong-ling
AU  - Yu HL
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Sichuan Da Xue Xue Bao Yi Xue Ban
JT  - Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical 
      science edition
JID - 101162609
RN  - 0 (Ghrelin)
RN  - 106388-42-5 (Peptide YY)
RN  - 89750-14-1 (Glucagon-Like Peptide 1)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Female
MH  - Ghrelin/*blood
MH  - Glucagon-Like Peptide 1/*blood
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Peptide YY/*blood
EDAT- 2013/12/12 06:00
MHDA- 2014/08/30 06:00
CRDT- 2013/12/12 06:00
PHST- 2013/12/12 06:00 [entrez]
PHST- 2013/12/12 06:00 [pubmed]
PHST- 2014/08/30 06:00 [medline]
PST - ppublish
SO  - Sichuan Da Xue Xue Bao Yi Xue Ban. 2013 Sep;44(5):774-8.