PMID- 24325919
OWN - NLM
STAT- MEDLINE
DCOM- 20140923
LR  - 20140128
IS  - 1878-1519 (Electronic)
IS  - 1569-9048 (Linking)
VI  - 192
DP  - 2014 Feb 1
TI  - Central ventilatory and cardiovascular actions of serotonin in trout.
PG  - 55-65
LID - S1569-9048(13)00388-1 [pii]
LID - 10.1016/j.resp.2013.12.001 [doi]
AB  - This study was undertaken to investigate the central actions of 5-HT on 
      ventilatory and cardiovascular variables in the unanesthetized trout. Compared to 
      vehicle, intracerebroventricular injection (ICV) of 5-HT elevated the total 
      ventilation. This elevation was due to its stimulatory action on ventilatory 
      amplitude. Moreover, 5-HT produced a dose-dependent increase in mean dorsal 
      aortic blood pressure (PDA) without change in heart rate (fH). Methysergide, a 
      5-HT1/5-HT2 receptor antagonist, reduced the hyperventilatory and hypertensive 
      actions of 5-HT. 8-OH-2-(di-n-propylamino) tetralin, a 5-HT1A receptor agonist, 
      increased PDA while alpha-methyl-5-HT, a 5-HT2 receptor agonist, elevated all 
      ventilatory variables and increased PDA without changing fH. Intra-arterial 
      injection of 5-HT was without effect on ventilation, but 5-HT initially produced 
      hypotension followed by hypertension. These changes were accompanied by 
      tachycardia. It remains to be determined whether endogenous 5-HT within the brain 
      of trout may act as a potent neuroregulator causing stimulatory effects on 
      cardio-ventilatory functions. In the periphery, 5-HT may act as local modulator 
      involved in vasoregulatory mechanisms.
CI  - Copyright (c) 2013 Elsevier B.V. All rights reserved.
FAU - Kermorgant, Marc
AU  - Kermorgant M
AD  - Universite Europeenne de Bretagne, Universite de Brest, INSERM U650, Laboratoire 
      de Traitement de l'Information Medicale, Laboratoire de Neurophysiologie, SFR 148 
      ScInBioS, Faculte de Medecine et des Sciences de la Sante, 22 avenue Camille 
      Desmoulins, CS 93837, CHU de Brest, 29238 Brest Cedex 3, France.
FAU - Lancien, Frederic
AU  - Lancien F
AD  - Universite Europeenne de Bretagne, Universite de Brest, INSERM U650, Laboratoire 
      de Traitement de l'Information Medicale, Laboratoire de Neurophysiologie, SFR 148 
      ScInBioS, Faculte de Medecine et des Sciences de la Sante, 22 avenue Camille 
      Desmoulins, CS 93837, CHU de Brest, 29238 Brest Cedex 3, France.
FAU - Mimassi, Nagi
AU  - Mimassi N
AD  - Universite Europeenne de Bretagne, Universite de Brest, INSERM U650, Laboratoire 
      de Traitement de l'Information Medicale, Laboratoire de Neurophysiologie, SFR 148 
      ScInBioS, Faculte de Medecine et des Sciences de la Sante, 22 avenue Camille 
      Desmoulins, CS 93837, CHU de Brest, 29238 Brest Cedex 3, France.
FAU - Le Mevel, Jean-Claude
AU  - Le Mevel JC
AD  - Universite Europeenne de Bretagne, Universite de Brest, INSERM U650, Laboratoire 
      de Traitement de l'Information Medicale, Laboratoire de Neurophysiologie, SFR 148 
      ScInBioS, Faculte de Medecine et des Sciences de la Sante, 22 avenue Camille 
      Desmoulins, CS 93837, CHU de Brest, 29238 Brest Cedex 3, France. Electronic 
      address: jean-claude.lemevel@univ-brest.fr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131208
PL  - Netherlands
TA  - Respir Physiol Neurobiol
JT  - Respiratory physiology & neurobiology
JID - 101140022
RN  - 0 (Serotonin Agents)
RN  - 333DO1RDJY (Serotonin)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Blood Pressure/*drug effects
MH  - Drug Interactions
MH  - Injections, Intraventricular
MH  - Respiration/*drug effects
MH  - Serotonin/*pharmacology
MH  - Serotonin Agents/*pharmacology
MH  - Trout
OTO - NOTNLM
OT  - 5-HT receptors
OT  - Central 5-HT
OT  - Hypertension
OT  - Hyperventilation
OT  - Intracerebroventricular injection
OT  - Teleost
EDAT- 2013/12/12 06:00
MHDA- 2014/09/24 06:00
CRDT- 2013/12/12 06:00
PHST- 2013/10/02 00:00 [received]
PHST- 2013/11/20 00:00 [revised]
PHST- 2013/12/02 00:00 [accepted]
PHST- 2013/12/12 06:00 [entrez]
PHST- 2013/12/12 06:00 [pubmed]
PHST- 2014/09/24 06:00 [medline]
AID - S1569-9048(13)00388-1 [pii]
AID - 10.1016/j.resp.2013.12.001 [doi]
PST - ppublish
SO  - Respir Physiol Neurobiol. 2014 Feb 1;192:55-65. doi: 10.1016/j.resp.2013.12.001. 
      Epub 2013 Dec 8.