PMID- 24326547
OWN - NLM
STAT- MEDLINE
DCOM- 20140926
LR  - 20220716
IS  - 1529-1774 (Electronic)
IS  - 1087-0024 (Linking)
VI  - 16
IP  - 1
DP  - 2013 Dec
TI  - What can the genetics of psoriasis teach us about alopecia areata?
PG  - S34-6
LID - 10.1038/jidsymp.2013.10 [doi]
AB  - Previous genetic epidemiological studies of psoriasis and alopecia areata 
      demonstrated strong heritability in first-degree relatives and in twins. In 
      recent years, these two conditions have emerged as two skin diseases that are 
      starting to yield their secrets through genome-wide association studies. Both 
      diseases manifest prominent human leukocyte antigen (HLA) associations, psoriasis 
      primarily with major histocompatibility complex (MHC) Class 1, specifically 
      HLA-Cw6, and alopecia areata primarily with MHC Class II. Despite these 
      differences in HLA associations, both diseases have in common a prominent role 
      for CD8+ lymphocytes. The purpose of this brief review is to present the recent 
      developments in the genetics of psoriasis.
FAU - Elder, James T
AU  - Elder JT
AD  - Department of Dermatology, University of Michigan Medical School and Ann Arbor VA 
      Hospital, Ann Arbor, Michigan, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - J Investig Dermatol Symp Proc
JT  - The journal of investigative dermatology. Symposium proceedings
JID - 9609059
RN  - 0 (HLA-C Antigens)
RN  - 0 (HLA-C*06 antigen)
SB  - IM
MH  - Alopecia Areata/*genetics/immunology
MH  - CD8-Positive T-Lymphocytes
MH  - HLA-C Antigens
MH  - Humans
MH  - Psoriasis/*genetics/immunology
EDAT- 2013/12/12 06:00
MHDA- 2014/09/27 06:00
CRDT- 2013/12/12 06:00
PHST- 2013/12/12 06:00 [entrez]
PHST- 2013/12/12 06:00 [pubmed]
PHST- 2014/09/27 06:00 [medline]
AID - S1087-0024(15)30526-8 [pii]
AID - 10.1038/jidsymp.2013.10 [doi]
PST - ppublish
SO  - J Investig Dermatol Symp Proc. 2013 Dec;16(1):S34-6. doi: 
      10.1038/jidsymp.2013.10.