PMID- 24326685
OWN - NLM
STAT- MEDLINE
DCOM- 20140829
LR  - 20131219
IS  - 2042-650X (Electronic)
IS  - 2042-6496 (Linking)
VI  - 5
IP  - 1
DP  - 2014 Jan
TI  - Astaxanthin alleviates brain aging in rats by attenuating oxidative stress and 
      increasing BDNF levels.
PG  - 158-66
LID - 10.1039/c3fo60400d [doi]
AB  - Astaxanthin (AST) is a carotenoid pigment which possesses potent antioxidative, 
      anti-inflammatory, and neuroprotective properties. The aim of this study was to 
      investigate whether administration of AST had protective effects on 
      D-galactose-induced brain aging in rats, and further examined its protective 
      mechanisms. The results showed that AST treatment significantly restored the 
      activities of glutathione peroxidase (GSH-PX) and superoxide dismutase (SOD), and 
      increased glutathione (GSH) contents and total antioxidant capacity (T-AOC), but 
      decreased malondialdehyde (MDA), protein carbonylation and 8-hydroxy-2- 
      deoxyguanosine (8-OHdG) levels in the brains of aging rats. Furthermore, AST 
      increased the ratio of Bcl-2/Bax, but decreased the expression of 
      Cyclooxygenase-2 (COX-2) in the brains of aging rats. Additionally, AST 
      ameliorated histopathological changes in the hippocampus and restored brain 
      derived neurotrophic factor (BDNF) levels in both the brains and hippocampus of 
      aging rats. These results suggested that AST could alleviate brain aging, which 
      may be due to attenuating oxidative stress, ameliorating hippocampus damage, and 
      upregulating BDNF expression.
FAU - Wu, Wanqiang
AU  - Wu W
AD  - College of Food Science and Engineering, Northwest A&F University, 28. Xi-nong 
      Road, Yangling 712100, China. xueboliu@yahoo.com.cn.
FAU - Wang, Xin
AU  - Wang X
FAU - Xiang, Qisen
AU  - Xiang Q
FAU - Meng, Xu
AU  - Meng X
FAU - Peng, Ye
AU  - Peng Y
FAU - Du, Na
AU  - Du N
FAU - Liu, Zhigang
AU  - Liu Z
FAU - Sun, Quancai
AU  - Sun Q
FAU - Wang, Chan
AU  - Wang C
FAU - Liu, Xuebo
AU  - Liu X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Food Funct
JT  - Food & function
JID - 101549033
RN  - 0 (Antioxidants)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Protective Agents)
RN  - 0 (Xanthophylls)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - 8XPW32PR7I (astaxanthine)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - EC 3.4.22.- (Caspase 3)
SB  - IM
MH  - Aging/*drug effects/metabolism
MH  - Animals
MH  - Antioxidants/pharmacology
MH  - Brain/*drug effects/enzymology/growth & development/*metabolism
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Caspase 3/metabolism
MH  - Glutathione Peroxidase/metabolism
MH  - Humans
MH  - Male
MH  - Malondialdehyde/metabolism
MH  - Oxidative Stress/*drug effects
MH  - Protective Agents/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Superoxide Dismutase/metabolism
MH  - Xanthophylls/pharmacology
EDAT- 2013/12/12 06:00
MHDA- 2014/08/30 06:00
CRDT- 2013/12/12 06:00
PHST- 2013/12/12 06:00 [entrez]
PHST- 2013/12/12 06:00 [pubmed]
PHST- 2014/08/30 06:00 [medline]
AID - 10.1039/c3fo60400d [doi]
PST - ppublish
SO  - Food Funct. 2014 Jan;5(1):158-66. doi: 10.1039/c3fo60400d.