PMID- 24327369
OWN - NLM
STAT- MEDLINE
DCOM- 20141204
LR  - 20220408
IS  - 2047-2927 (Electronic)
IS  - 2047-2919 (Linking)
VI  - 2
IP  - 2
DP  - 2014 Mar
TI  - Single-nucleotide polymorphism, rs1799941 in the Sex Hormone-Binding Globulin 
      (SHBG) gene, related to both serum testosterone and SHBG levels and the risk of 
      myocardial infarction, type 2 diabetes, cancer and mortality in men: the Tromso 
      Study.
PG  - 212-8
LID - 10.1111/j.2047-2927.2013.00174.x [doi]
AB  - Low testosterone levels are associated with metabolic and cardiovascular disease 
      risk factor, and have been shown to predict type 2 diabetes mellitus (T2DM), 
      myocardial infarction (MI) and all-cause mortality. It is not known if these 
      associations are causal or not. Recently, it has been shown that the serum 
      testosterone levels are associated with single-nucleotide polymorphisms (SNPs), 
      and we therefore studied the associations between one of these SNPs, rs1799941 on 
      the Sex Hormone-Binding Globulin (SHBG) gene, and MI, T2DM, cancer and death. DNA 
      was prepared from men who participated in the fourth survey of the Tromso Study 
      in 1994-1995 and who were registered with the endpoints MI, T2DM, cancer or death 
      and a randomly selected control group. For mortality, the observation time was 
      set from 1994, and for the other endpoints from birth. The endpoint data were 
      completed up to 2010-2013. Genetic analyses were successfully performed in 5309 
      men, of whom 1454 were registered with MI, 638 with T2DM, 1534 with cancer and in 
      2226 who had died. Men with the minor homozygote genotype had significantly 
      higher levels of total testosterone (14.7%) and SHBG (24.7%) compared with men 
      with the major homozygote genotype, whereas free testosterone levels did not 
      differ significantly between the genotypes. The SNP rs1799941 was not 
      significantly associated with MI, T2DM, cancer or mortality. Thus, our result 
      does not support a causal relationship between total testosterone and SHBG and 
      MI, T2DM, cancer or mortality, suggesting that low testosterone more likely is a 
      marker of poor health.
CI  - (c) 2013 American Society of Andrology and European Academy of Andrology.
FAU - Svartberg, J
AU  - Svartberg J
AD  - Tromso Endocrine Research Group, Department of Clinical Medicine, UiT The Arctic 
      University of Norway, Tromso, Norway; Division of Internal Medicine, University 
      Hospital of North Norway, Tromso, Norway.
FAU - Schirmer, H
AU  - Schirmer H
FAU - Wilsgaard, T
AU  - Wilsgaard T
FAU - Mathiesen, E B
AU  - Mathiesen EB
FAU - Njolstad, I
AU  - Njolstad I
FAU - Lochen, M-L
AU  - Lochen ML
FAU - Jorde, R
AU  - Jorde R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131210
PL  - England
TA  - Andrology
JT  - Andrology
JID - 101585129
RN  - 0 (Sex Hormone-Binding Globulin)
RN  - 3XMK78S47O (Testosterone)
SB  - IM
MH  - Aged
MH  - Diabetes Mellitus, Type 2/blood/*epidemiology/mortality
MH  - Epidemiologic Studies
MH  - Genotype
MH  - Humans
MH  - Life Style
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/blood/*epidemiology/mortality
MH  - Neoplasms/blood/*epidemiology/mortality
MH  - Polymorphism, Single Nucleotide
MH  - Sex Hormone-Binding Globulin/*genetics
MH  - Surveys and Questionnaires
MH  - Testosterone/*blood
OTO - NOTNLM
OT  - SNP
OT  - cancer
OT  - cardiovascular disease
OT  - diabetes
OT  - epidemiology
OT  - mortality
OT  - testosterone
EDAT- 2013/12/12 06:00
MHDA- 2014/12/15 06:00
CRDT- 2013/12/12 06:00
PHST- 2013/10/10 00:00 [received]
PHST- 2013/11/07 00:00 [revised]
PHST- 2013/11/20 00:00 [accepted]
PHST- 2013/12/12 06:00 [entrez]
PHST- 2013/12/12 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - 10.1111/j.2047-2927.2013.00174.x [doi]
PST - ppublish
SO  - Andrology. 2014 Mar;2(2):212-8. doi: 10.1111/j.2047-2927.2013.00174.x. Epub 2013 
      Dec 10.