PMID- 24327957
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20131211
LR  - 20211021
IS  - 2212-8778 (Print)
IS  - 2212-8778 (Electronic)
IS  - 2212-8778 (Linking)
VI  - 2
IP  - 4
DP  - 2013
TI  - Diet-induced changes in the Lean Brain: Hypercaloric high-fat-high-sugar snacking 
      decreases serotonin transporters in the human hypothalamic region.
PG  - 417-22
LID - 10.1016/j.molmet.2013.07.006 [doi]
AB  - It is evident that there is a relationship between the brain's serotonin system 
      and obesity. Although it is clear that drugs affecting the serotonin system 
      regulate appetite and food intake, it is unclear whether changes in the serotonin 
      system are cause or consequence of obesity. To determine whether obesogenic 
      eating habits result in reduced serotonin transporter (SERT)-binding in the human 
      hypothalamic region, we included 25 lean, male subjects who followed a 
      6-week-hypercaloric diet, which were high-fat-high-sugar (HFHS) or high-sugar 
      (HS) with increased meal size or -frequency (=snacking pattern). We measured 
      SERT-binding in the hypothalamic region with SPECT. All hypercaloric diets 
      significantly increased body weight by 3-3.5%. Although there were no differences 
      in total calories consumed between the diets, only a hypercaloric HFHS-snacking 
      diet decreased SERT-binding significantly by 30%. We here show for the first time 
      in humans that snacking may change the serotonergic system increasing the risk to 
      develop obesity.
FAU - Koopman, Karin Eva
AU  - Koopman KE
AD  - Department of Endocrinology & Metabolism, Academic Medical Center, University of 
      Amsterdam; Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
FAU - Booij, Jan
AU  - Booij J
FAU - Fliers, Eric
AU  - Fliers E
FAU - Serlie, Mireille Johanna
AU  - Serlie MJ
FAU - la Fleur, Susanne Eva
AU  - la Fleur SE
LA  - eng
PT  - Journal Article
DEP - 20130807
PL  - Germany
TA  - Mol Metab
JT  - Molecular metabolism
JID - 101605730
PMC - PMC3855045
OTO - NOTNLM
OT  - Fat
OT  - Human imaging
OT  - Hypercaloric diet
OT  - Meal pattern
OT  - Serotonin transporters
OT  - Sugar
EDAT- 2013/12/12 06:00
MHDA- 2013/12/12 06:01
PMCR- 2013/08/07
CRDT- 2013/12/12 06:00
PHST- 2013/07/17 00:00 [received]
PHST- 2013/07/21 00:00 [accepted]
PHST- 2013/12/12 06:00 [entrez]
PHST- 2013/12/12 06:00 [pubmed]
PHST- 2013/12/12 06:01 [medline]
PHST- 2013/08/07 00:00 [pmc-release]
AID - S2212-8778(13)00066-5 [pii]
AID - 10.1016/j.molmet.2013.07.006 [doi]
PST - epublish
SO  - Mol Metab. 2013 Aug 7;2(4):417-22. doi: 10.1016/j.molmet.2013.07.006. eCollection 
      2013.