PMID- 24327964
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20131211
LR  - 20211021
IS  - 2212-8778 (Print)
IS  - 2212-8778 (Electronic)
IS  - 2212-8778 (Linking)
VI  - 2
IP  - 4
DP  - 2013
TI  - Ablation of TrkB expression in RGS9-2 cells leads to hyperphagic obesity.
PG  - 491-7
LID - 10.1016/j.molmet.2013.08.002 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) and its cognate receptor, TrkB 
      (tropomyosin receptor kinase B), are widely expressed in the brain where they 
      regulate a wide variety of biological processes, including energy homeostasis. 
      However, the specific population(s) of TrkB-expressing neurons through which BDNF 
      governs energy homeostasis remain(s) to be determined. Using the Cre-loxP 
      recombination system, we deleted the mouse TrkB gene in RGS9-2-expressing cells. 
      In this mouse mutant, TrkB expression was abolished in several hypothalamic 
      nuclei, including arcuate nucleus, dorsomedial hypothalamus, and lateral 
      hypothalamus. TrkB expression was also abolished in a small number of cells in 
      other brain regions, including the cerebral cortex and striatum. The mutant 
      animals developed hyperphagic obesity with normal energy expenditure. Despite 
      hyperglycemia under fed conditions, these animals exhibited normal fasting blood 
      glucose levels and normal glucose tolerance. These results suggest that BDNF 
      regulates energy homeostasis in part through TrkB-expressing neurons in the 
      hypothalamus.
FAU - Liao, Guey-Ying
AU  - Liao GY
AD  - Department of Pharmacology and Physiology, Georgetown University Medical Center, 
      Washington, DC 20057, USA ; Department of Neuroscience, The Scripps Research 
      Institute Florida, Jupiter, FL 33458, USA.
FAU - Li, Yuqing
AU  - Li Y
FAU - Xu, Baoji
AU  - Xu B
LA  - eng
GR  - R01 DK089237/DK/NIDDK NIH HHS/United States
PT  - Journal Article
DEP - 20130809
PL  - Germany
TA  - Mol Metab
JT  - Molecular metabolism
JID - 101605730
PMC - PMC3854990
OTO - NOTNLM
OT  - 3V, third ventricle
OT  - ARC, arcuate nucleus
OT  - BDNF
OT  - BS, brainstem
OT  - Cb, cerebellum
OT  - Ctx, cerebral cortex
OT  - DMH, dorsomedial hypothalamus
OT  - Hp, hippocampus
OT  - Hy, hypothalamus
OT  - Hyperphagia
OT  - Hypothalamus
OT  - LH, lateral hypothalamus
OT  - NTS, nucleus of the solitary tract
OT  - Obesity
OT  - PMV, ventral premammillary nucleus
OT  - PVH, paraventricular hypothalamus
OT  - Rgs9-Cre
OT  - SN, substantia nigra
OT  - Stm, striatum
OT  - TrkB
OT  - Tu, olfactory tubercle
OT  - VMH, ventromedial hypothalamus
EDAT- 2013/12/12 06:00
MHDA- 2013/12/12 06:01
PMCR- 2013/08/09
CRDT- 2013/12/12 06:00
PHST- 2013/07/24 00:00 [received]
PHST- 2013/07/31 00:00 [revised]
PHST- 2013/08/03 00:00 [accepted]
PHST- 2013/12/12 06:00 [entrez]
PHST- 2013/12/12 06:00 [pubmed]
PHST- 2013/12/12 06:01 [medline]
PHST- 2013/08/09 00:00 [pmc-release]
AID - S2212-8778(13)00071-9 [pii]
AID - 10.1016/j.molmet.2013.08.002 [doi]
PST - epublish
SO  - Mol Metab. 2013 Aug 9;2(4):491-7. doi: 10.1016/j.molmet.2013.08.002. eCollection 
      2013.