PMID- 24328563
OWN - NLM
STAT- MEDLINE
DCOM- 20140714
LR  - 20131216
IS  - 1532-2335 (Electronic)
IS  - 1525-7770 (Linking)
VI  - 32
IP  - 12
DP  - 2013
TI  - Probing the site-selective binding of an antiretroviral drug, Stavudine to calf 
      thymus DNA.
PG  - 660-9
LID - 10.1080/15257770.2013.851392 [doi]
AB  - The interaction of an anti-HIV drug, stavudine (STV) with calf thymus 
      deoxyribonucleic acid (DNA) was investigated employing acridine orange (AO) as a 
      fluorescence probe. Spectroscopic investigations revealed the intercalative mode 
      of binding of STV to DNA. The analysis of fluorescence data indicated the 
      presence of static quenching mechanism between STV and DNA. Thermodynamic 
      parameters indicated the presence of van der Waals forces in addition to 
      intercalative mode of binding. CD data revealed the partial B --> A conformational 
      transition of DNA upon intercalative mode of binding with STV.
FAU - Sandhya, B
AU  - Sandhya B
AD  - a Department of Chemistry , Karnatak University , Dharwad , Karnataka , India.
FAU - Seetharamappa, J
AU  - Seetharamappa J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Nucleosides Nucleotides Nucleic Acids
JT  - Nucleosides, nucleotides & nucleic acids
JID - 100892832
RN  - 0 (Anti-HIV Agents)
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Intercalating Agents)
RN  - 9007-49-2 (DNA)
RN  - 91080-16-9 (calf thymus DNA)
RN  - BO9LE4QFZF (Stavudine)
SB  - IM
MH  - Animals
MH  - Anti-HIV Agents/chemistry/*pharmacology
MH  - Antineoplastic Agents/chemistry/*pharmacology
MH  - Binding Sites
MH  - Cattle
MH  - DNA/chemistry/*metabolism
MH  - *Drug Discovery
MH  - Intercalating Agents/chemistry/*pharmacology
MH  - Nucleic Acid Denaturation/drug effects
MH  - Spectrometry, Fluorescence
MH  - Stavudine/chemistry/*pharmacology
MH  - Thermodynamics
EDAT- 2013/12/18 06:00
MHDA- 2014/07/16 06:00
CRDT- 2013/12/17 06:00
PHST- 2013/12/17 06:00 [entrez]
PHST- 2013/12/18 06:00 [pubmed]
PHST- 2014/07/16 06:00 [medline]
AID - 10.1080/15257770.2013.851392 [doi]
PST - ppublish
SO  - Nucleosides Nucleotides Nucleic Acids. 2013;32(12):660-9. doi: 
      10.1080/15257770.2013.851392.