PMID- 24329127
OWN - NLM
STAT- MEDLINE
DCOM- 20140820
LR  - 20131224
IS  - 1940-1027 (Electronic)
IS  - 0022-2895 (Linking)
VI  - 46
IP  - 1
DP  - 2014
TI  - BDNF 196 G/A and 270 C/T polymorphisms and susceptibility to Parkinson's disease: 
      a meta-analysis.
PG  - 59-66
LID - 10.1080/00222895.2013.862199 [doi]
AB  - ABSTRACT The aim of this study was to explore whether brain-derived neurotrophic 
      factor (BDNF) polymorphisms 196 G/A and 270 C/T confer susceptibility to 
      Parkinson's disease (PD). The authors conducted a meta-analysis of the 
      associations between the BDNF 196 G/A and 270 C/T polymorphisms and PD in 
      subjects. They considered 12 studies in the case of the BDNF 196 G/A polymorphism 
      and 4 studies in the case of the BDNF 270 C/T polymorphism. Meta-analysis showed 
      no association between PD and the BDNF 196A allele in all study subjects (odds 
      ratio [OR] = 1.066, 95% CI [0.972, 1.169], p = .173). However, ethnicity-specific 
      meta-analysis identified an association between the BDNF 196 AA + AG genotype and 
      PD in Europeans, but not in Asians (OR = 1.212, 95% CI [1.007, 1.458], p = .042; 
      OR = 1.0567, 95% CI [0.913, 1.221], p = .465). Meta-analysis showed no 
      association between PD and the BDNF 270 C/T polymorphism (OR for the T allele = 
      1.213, 95% CI [0.923, 1.595], p = .165). This meta-analysis identified an 
      association between the BDNF 196 G/A polymorphism in Europeans, but not in 
      Asians, but failed to identify an association between the BDNF 270 C/T 
      polymorphism and PD.
FAU - Lee, Young Ho
AU  - Lee YH
AD  - a Division of Rheumatology, Department of Internal Medicine , Korea University 
      College of Medicine , Seoul.
FAU - Song, Gwan Gyu
AU  - Song GG
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
DEP - 20131212
PL  - United States
TA  - J Mot Behav
JT  - Journal of motor behavior
JID - 0236512
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Data Interpretation, Statistical
MH  - Genetic Predisposition to Disease/*genetics
MH  - Humans
MH  - Parkinson Disease/*genetics
MH  - Polymorphism, Genetic/genetics/*physiology
MH  - Publication Bias
MH  - Research Design
EDAT- 2013/12/18 06:00
MHDA- 2014/08/21 06:00
CRDT- 2013/12/17 06:00
PHST- 2013/12/17 06:00 [entrez]
PHST- 2013/12/18 06:00 [pubmed]
PHST- 2014/08/21 06:00 [medline]
AID - 10.1080/00222895.2013.862199 [doi]
PST - ppublish
SO  - J Mot Behav. 2014;46(1):59-66. doi: 10.1080/00222895.2013.862199. Epub 2013 Dec 
      12.