PMID- 24331565
OWN - NLM
STAT- MEDLINE
DCOM- 20140212
LR  - 20131216
IS  - 1531-5053 (Electronic)
IS  - 0278-2391 (Linking)
VI  - 72
IP  - 1
DP  - 2014 Jan
TI  - Hydroxyapatite and collagen combination-coated dental implants display better 
      bone formation in the peri-implant area than the same combination plus bone 
      morphogenetic protein-2-coated implants, hydroxyapatite only coated implants, and 
      uncoated implants.
PG  - 53-60
LID - S0278-2391(13)01140-3 [pii]
LID - 10.1016/j.joms.2013.08.031 [doi]
AB  - PURPOSE: The objective of this study was to compare peri-implant bone formation 
      among uncoated (UC), hydroxyapatite (HA), collagen plus HA (CH), and collagen, 
      HA, plus bone morphogenetic protein-2 (BMP-2) implant groups. MATERIALS AND 
      METHODS: Implants in the UC group had acid-etched surfaces. The surface coating 
      was applied using the aerosol deposition method. The coated surfaces were 
      examined by scanning electron microscopy, x-ray diffraction (XRD), and 
      Fourier-transformed infrared absorption analysis. Subsequently, 6 implants from 
      each group (total, 24 implants) were installed in the tibias of rabbits. The 
      animals were sacrificed at 6 weeks after implant installation. Peri-implant bone 
      formation and bone-to-implant contact (BIC) were measured in histologic sections. 
      Significant differences among groups were evaluated using analysis of variance. 
      RESULTS: Based on the measured XRD patterns, there was a characteristic HA phase 
      (International Centre for Diffraction Data [ICDD], 086-0740) coated on the 
      titanium (ICDD, 089-3725). Subsequent coating processes for collagen and BMP-2 
      did not display additional diffraction peaks, but maintained the diffraction 
      patterns of the HA-coated titanium. The presence of collagen was verified by 
      infrared absorption analysis. When comparing these modifications with UC 
      surfaces, only the CH coating displayed significantly greater peri-implant bone 
      formation and BIC (P = .003 and P < .001, respectively). Adding BMP-2 to the 
      implant surface did not produce any advantage compared with the CH coating. 
      CONCLUSIONS: In this study, the CH group displayed significantly greater new bone 
      formation and BIC than the other groups. There was no significant difference 
      among the other groups.
CI  - Copyright (c) 2014 American Association of Oral and Maxillofacial Surgeons. 
      Published by Elsevier Inc. All rights reserved.
FAU - Lee, Sang-Woon
AU  - Lee SW
AD  - Fellow, Department of Oral and Maxillofacial Surgery, College of Dentistry, 
      Gangneung-Wonju National University, Gangneung, Korea.
FAU - Hahn, Byung-Dong
AU  - Hahn BD
AD  - Researcher, Functional Materials Division, Korea Institute of Materials Science, 
      Changwon, Korea.
FAU - Kang, Tae Yeon
AU  - Kang TY
AD  - Researcher, Gangneung Center, Korea Basic Science Institute, Gangneung, Korea.
FAU - Lee, Myung-Jin
AU  - Lee MJ
AD  - Researcher, Gangneung Center, Korea Basic Science Institute, Gangneung, Korea.
FAU - Choi, Je-Yong
AU  - Choi JY
AD  - Professor, School of Biochemistry and Cell Biology, WCU Project, Skeletal 
      Diseases Genome Research Center, Kyungpook National University, Daegu, Korea.
FAU - Kim, Min-Keun
AU  - Kim MK
AD  - Assistant Professor, Department of Oral and Maxillofacial Surgery, College of 
      Dentistry, Gangneung-Wonju National University, Gangneung, Korea.
FAU - Kim, Seong-Gon
AU  - Kim SG
AD  - Associate Professor, Department of Oral and Maxillofacial Surgery, College of 
      Dentistry, Gangneung-Wonju National University, Gangneung, Korea. Electronic 
      address: epker@chol.com.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Oral Maxillofac Surg
JT  - Journal of oral and maxillofacial surgery : official journal of the American 
      Association of Oral and Maxillofacial Surgeons
JID - 8206428
RN  - 0 (Aerosols)
RN  - 0 (BMP2 protein, human)
RN  - 0 (Bone Morphogenetic Protein 2)
RN  - 0 (Coated Materials, Biocompatible)
RN  - 0 (Collagen Type I)
RN  - 0 (Dental Implants)
RN  - 0 (Dental Materials)
RN  - 91D9GV0Z28 (Durapatite)
RN  - D1JT611TNE (Titanium)
SB  - IM
MH  - Acid Etching, Dental/methods
MH  - Aerosols
MH  - Animals
MH  - Bone Morphogenetic Protein 2/*chemistry
MH  - Coated Materials, Biocompatible/*chemistry
MH  - Collagen Type I/*chemistry
MH  - *Dental Implants
MH  - Dental Materials/chemistry
MH  - *Dental Prosthesis Design
MH  - Durapatite/*chemistry
MH  - Materials Testing
MH  - Microscopy, Electron, Scanning
MH  - Osseointegration/physiology
MH  - Osteogenesis/*physiology
MH  - Rabbits
MH  - Spectroscopy, Fourier Transform Infrared
MH  - Surface Properties
MH  - Tibia/pathology/surgery
MH  - Titanium/chemistry
MH  - X-Ray Diffraction
EDAT- 2013/12/18 06:00
MHDA- 2014/02/13 06:00
CRDT- 2013/12/17 06:00
PHST- 2013/06/13 00:00 [received]
PHST- 2013/07/30 00:00 [revised]
PHST- 2013/08/28 00:00 [accepted]
PHST- 2013/12/17 06:00 [entrez]
PHST- 2013/12/18 06:00 [pubmed]
PHST- 2014/02/13 06:00 [medline]
AID - S0278-2391(13)01140-3 [pii]
AID - 10.1016/j.joms.2013.08.031 [doi]
PST - ppublish
SO  - J Oral Maxillofac Surg. 2014 Jan;72(1):53-60. doi: 10.1016/j.joms.2013.08.031.