PMID- 24331771
OWN - NLM
STAT- MEDLINE
DCOM- 20140728
LR  - 20181202
IS  - 1871-403X (Print)
IS  - 1871-403X (Linking)
VI  - 7
IP  - 2
DP  - 2013 Mar-Apr
TI  - Beneficial effects of Chlorella on glucose and lipid metabolism in obese rodents 
      on a high-fat diet.
PG  - e95-e105
LID - S1871-403X(13)00009-4 [pii]
LID - 10.1016/j.orcp.2013.01.002 [doi]
AB  - BACKGROUND: Obesity-induced glucose and lipid metabolism disorders have become 
      risk factors for lifestyle diseases. Powderized Parachlorella beijerinckii (BP) 
      and its hot water extract (BCEx) are believed to be useful for preventing common 
      diseases such as hypertension, arteriosclerosis, and hyperlipidemia. The present 
      study investigated how chlorella components influence common diseases in obese 
      mice and rats on a high-fat diet. METHODS: We fed C57BL/6J mice a high-fat diet 
      containing 5% BP, and then weighed their organs, tested their glucose tolerance 
      and insulin sensitivity, and analyzed their serum. Further, we fed Sprague-Dawley 
      rats with a high-fat diet containing 1% BCEx, and then weighed their organs and 
      analyzed their serum parameters. RESULTS: BP administration had no effect on 
      high-fat diet-induced obesity. However, compared with high-fat diet group, BP 
      group had improved glucose tolerance and insulin sensitivity and inhibited the 
      hypertrophic growth of visceral fat cells. In addition, BP group had improved 
      serum adiponectin, leptin and monocyte chemoattractant protein-1 (MCP-1) levels. 
      The MCP-1 expression level at epididymal fat was decreased at BP group. BCEx 
      administration reduced amount of peritesticular fat and serum triglyceride (TG) 
      levels. CONCLUSIONS: The results suggest that the antihyperinsulinemic effects of 
      BP are due to the modulation of adipose tissue hypertrophy and adipocytokine 
      secretion. BCEx inhibited the accumulation of visceral fat and serum TG. The 
      study showed that BP and BCEx improve glucose and lipid metabolism disorders 
      caused by a high-fat diet.
CI  - A(c) 2013 Asian Oceanian Association for the Study of Obesity . Published by 
      Elsevier Ltd. All rights reserved.
FAU - Noguchi, Naoto
AU  - Noguchi N
AD  - Department of Research & Development, Chlorella Industry Co., Ltd., 1343 
      Hisatomi, Chikugo, Fukuoka 833-0056, Japan. Electronic 
      address:naoto_noguchi@chlorella.co.jp.
FAU - Konishi, Fumiko
AU  - Konishi F
AD  - Department of Research & Development, Chlorella Industry Co., Ltd., 1343 
      Hisatomi, Chikugo, Fukuoka 833-0056, Japan.
FAU - Kumamoto, Shoichiro
AU  - Kumamoto S
AD  - Department of Research & Development, Chlorella Industry Co., Ltd., 1343 
      Hisatomi, Chikugo, Fukuoka 833-0056, Japan.
FAU - Maruyama, Isao
AU  - Maruyama I
AD  - Department of Research & Development, Chlorella Industry Co., Ltd., 1343 
      Hisatomi, Chikugo, Fukuoka 833-0056, Japan.
FAU - Ando, Yotaro
AU  - Ando Y
AD  - Department of Research & Development, Chlorella Industry Co., Ltd., 1343 
      Hisatomi, Chikugo, Fukuoka 833-0056, Japan.
FAU - Yanagita, Teruyoshi
AU  - Yanagita T
AD  - Department of Health and Nutrition Sciences, Faculty of Health and Social Welfare 
      Sciences, Nishikyushu University, 4490-9 Ozaki, Kanzaki, Saga 842-8585, Japan.
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Obes Res Clin Pract
JT  - Obesity research & clinical practice
JID - 101303911
RN  - 0 (Adipokines)
RN  - 0 (Blood Glucose)
RN  - 0 (Dietary Fats)
RN  - 0 (Insulin)
RN  - 0 (Plant Preparations)
RN  - 0 (Triglycerides)
SB  - IM
MH  - Adipocytes/drug effects/pathology
MH  - Adipokines/metabolism
MH  - Animals
MH  - Blood Glucose/*metabolism
MH  - *Chlorella
MH  - Diet, High-Fat/adverse effects
MH  - Dietary Fats/metabolism
MH  - Hyperinsulinism/*prevention & control
MH  - Hypertrophy
MH  - Insulin/blood
MH  - Insulin Resistance
MH  - Intra-Abdominal Fat/cytology/*metabolism/pathology
MH  - Lipid Metabolism/*drug effects
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Obese
MH  - Obesity/blood/drug therapy/etiology/*metabolism
MH  - *Phytotherapy
MH  - Plant Preparations/pharmacology/therapeutic use
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Triglycerides/blood
EDAT- 2013/12/18 06:00
MHDA- 2014/07/30 06:00
CRDT- 2013/12/17 06:00
PHST- 2012/11/26 00:00 [received]
PHST- 2013/01/08 00:00 [revised]
PHST- 2013/01/09 00:00 [accepted]
PHST- 2013/12/17 06:00 [entrez]
PHST- 2013/12/18 06:00 [pubmed]
PHST- 2014/07/30 06:00 [medline]
AID - S1871-403X(13)00009-4 [pii]
AID - 10.1016/j.orcp.2013.01.002 [doi]
PST - ppublish
SO  - Obes Res Clin Pract. 2013 Mar-Apr;7(2):e95-e105. doi: 10.1016/j.orcp.2013.01.002.