PMID- 24332590
OWN - NLM
STAT- MEDLINE
DCOM- 20141203
LR  - 20181202
IS  - 1532-2653 (Electronic)
IS  - 0967-5868 (Linking)
VI  - 21
IP  - 4
DP  - 2014 Apr
TI  - Clinicopathological features of myxopapillary ependymoma.
PG  - 569-73
LID - S0967-5868(13)00443-8 [pii]
LID - 10.1016/j.jocn.2013.05.028 [doi]
AB  - Myxopapillary ependymoma (MPE) is a rare and distinct variant of ependymoma with 
      a tendency for local recurrence and metastasis. Its clinicopathological spectrum 
      is heterogenous, underscoring the need to understand and characterize MPE for 
      better diagnosis and treatment. The purpose of this study was to explore the 
      tumor biology and assess the management of patients with MPE. Tumors from a 
      cohort of 19 patients were analyzed by light microscopy, electron microscopy, 
      immunohistochemistry and fluorescence in situ hybridization (FISH). Clinical 
      characteristics, therapeutic options and clinical follow-up data were also 
      analyzed. Back pain was the most common presenting symptom. The main pathological 
      morphology observed was papillae embedded in a myxoid background, but other rare 
      morphologies were also present. Immunostaining revealed epidermal growth factor 
      receptor (EGFR) expression in four MPE, while FISH for EGFR was negative. No 
      correlation between tumor recurrence and EGFR overexpression was found. 
      Ultrastructural examination revealed adherens junctions and intracytoplasmic 
      lumina with microvilli. Patients with gross-total resection (GTR) had no tumor 
      recurrence (p=0.021). Also, patients with subtotal resection (STR) followed by 
      radiotherapy showed a higher local control rate than patients with STR alone 
      (p=0.043). The diagnosis of MPE should be made considering the histology, 
      immunohistochemistry, imaging studies and anatomical site. GTR of the tumor or 
      STR followed by radiotherapy are more likely to avoid tumor recurrence than STR 
      alone. Based on our findings, there is no correlation between tumor recurrence 
      and EGFR expression.
CI  - Copyright (c) 2013 Elsevier Ltd. All rights reserved.
FAU - Wang, Hai
AU  - Wang H
AD  - Department of Pathology, Jinling Hospital, Nanjing University School of Medicine, 
      305 East Zhongshan Road, Nanjing 210002, China. Electronic address: 
      drwh77@hotmail.com.
FAU - Zhang, Shu
AU  - Zhang S
AD  - Department of Pathology, Affiliated Hospital of Nantong University, Nantong, 
      China.
FAU - Rehman, Sumaiyah K
AU  - Rehman SK
AD  - Department of Molecular & Cellular Oncology, The University of Texas MD Anderson 
      Cancer Center, Houston, TX, USA.
FAU - Zhang, Zhiyuan
AU  - Zhang Z
AD  - Department of Neurosurgery, Jinling Hospital, Nanjing University School of 
      Medicine, Nanjing 210002, China.
FAU - Li, Wanchun
AU  - Li W
AD  - Department of Pathology, Jinling Hospital, Nanjing University School of Medicine, 
      305 East Zhongshan Road, Nanjing 210002, China.
FAU - Makki, Mohammad Shahidul
AU  - Makki MS
AD  - Department of Molecular & Cellular Oncology, The University of Texas MD Anderson 
      Cancer Center, Houston, TX, USA.
FAU - Zhou, Xiaojun
AU  - Zhou X
AD  - Department of Pathology, Jinling Hospital, Nanjing University School of Medicine, 
      305 East Zhongshan Road, Nanjing 210002, China.
LA  - eng
PT  - Journal Article
DEP - 20130816
PL  - Scotland
TA  - J Clin Neurosci
JT  - Journal of clinical neuroscience : official journal of the Neurosurgical Society 
      of Australasia
JID - 9433352
RN  - EC 2.7.10.1 (EGFR protein, human)
RN  - EC 2.7.10.1 (ErbB Receptors)
SB  - IM
MH  - Adherens Junctions/ultrastructure
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Back Pain/etiology
MH  - Cohort Studies
MH  - Ependymoma/complications/*pathology/*physiopathology/therapy
MH  - ErbB Receptors/metabolism
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Microscopy, Electron
MH  - Middle Aged
MH  - Neoplasm Recurrence, Local
MH  - Spinal Cord Neoplasms/complications/*pathology/*physiopathology/therapy
MH  - Treatment Outcome
MH  - Young Adult
OTO - NOTNLM
OT  - EGFR
OT  - Immunohistochemistry
OT  - Myxopapillary ependymoma
OT  - Pathology
OT  - Radiotherapy
OT  - Ultrastructure
EDAT- 2013/12/18 06:00
MHDA- 2014/12/15 06:00
CRDT- 2013/12/17 06:00
PHST- 2013/03/09 00:00 [received]
PHST- 2013/05/22 00:00 [revised]
PHST- 2013/05/26 00:00 [accepted]
PHST- 2013/12/17 06:00 [entrez]
PHST- 2013/12/18 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - S0967-5868(13)00443-8 [pii]
AID - 10.1016/j.jocn.2013.05.028 [doi]
PST - ppublish
SO  - J Clin Neurosci. 2014 Apr;21(4):569-73. doi: 10.1016/j.jocn.2013.05.028. Epub 
      2013 Aug 16.