PMID- 24332848 OWN - NLM STAT- MEDLINE DCOM- 20141001 LR - 20140120 IS - 1872-7727 (Electronic) IS - 0720-048X (Linking) VI - 83 IP - 2 DP - 2014 Feb TI - T-wave inversions related to left ventricular basal hypertrophy and myocardial fibrosis in non-apical hypertrophic cardiomyopathy: a cardiovascular magnetic resonance imaging study. PG - 297-302 LID - S0720-048X(13)00582-2 [pii] LID - 10.1016/j.ejrad.2013.10.025 [doi] AB - OBJECTIVES: To investigate the relationship between T-wave inversions and left ventricular (LV) segmental hypertrophy and myocardial fibrosis assessed by cardiovascular magnetic resonance (CMR) in patients with non-apical hypertrophic cardiomyopathy (HCM). METHODS: 196 consecutive patients with non-apical HCM underwent late gadolinium enhancement (LGE) CMR and 12-lead electrocardiogram. The distribution and magnitude of LV segmental hypertrophy and LGE were assessed according to the AHA 17-segment model and analyzed in relation to T-wave inversions. RESULTS: Of 196 HCM patients, 144 (73%) exhibited T-wave inversions. 144 (73%) patients had evidence of myocardial fi brosis as defined by LGE, and the prevalence of LGE was significantly higher in patients with T-wave inversions compared with those without T-wave inversions (78% vs. 59%, P=0.008). T-wave inversions were related to basal anterior and basal anteroseptal LGE (20% vs. 10%, P=0.04 and 68% vs. 46%, P=0.005, respectively). In addition, T-wave inversions were associated with greater basal anteroseptal and basal inferior wall thickness (19.5 +/- 4.7 mm vs. 16.7 +/- 4.5mm, P<0.001 and 10.9 +/- 3.3mm vs. 9.6 +/- 3.0mm, P=0.01, respectively). By logistic regression analysis, basal anteroseptal wall thickness and LGE were independent determinants of T-wave inversions (P=0.005, P=0.01, respectively). CONCLUSIONS: T-wave inversions in HCM are associated with LGE and wall thickness of the left ventricular basal segments. Moreover, basal anteroseptal wall thickness and LGE are independent determinants of T-wave inversions. CI - Copyright (c) 2013 Elsevier Ireland Ltd. All rights reserved. FAU - Chen, Xiuyu AU - Chen X AD - Department of Radiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China. Electronic address: cxy0202@126.com. FAU - Zhao, Shihua AU - Zhao S AD - Department of Radiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China. Electronic address: zhaoshihua0202@126.com. FAU - Zhao, Tao AU - Zhao T AD - Department of Radiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China. Electronic address: taozhao0202@126.com. FAU - Lu, Minjie AU - Lu M AD - Department of Radiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China. Electronic address: lmjkan@126.com. FAU - Yin, Gang AU - Yin G AD - Department of Radiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China. Electronic address: gangyin0202@126.com. FAU - Jiang, Shiliang AU - Jiang S AD - Department of Radiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China. Electronic address: jiangsl-2011@163.com. FAU - Prasad, Sanjay AU - Prasad S AD - NIHR Biomedical Research Unit, Royal Brompton Hospital Sydney Street, London, SW3 6NP, United Kingdom. Electronic address: s.prasad@rbht.nhs.uk. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20131107 PL - Ireland TA - Eur J Radiol JT - European journal of radiology JID - 8106411 SB - IM MH - Arrhythmias, Cardiac/*diagnosis/*etiology MH - Electrocardiography MH - Female MH - Fibrosis MH - Humans MH - Hypertrophy, Left Ventricular/*complications/*diagnosis MH - Magnetic Resonance Imaging, Cine/*methods MH - Male MH - Middle Aged MH - Myocardium/*pathology MH - Reproducibility of Results MH - Sensitivity and Specificity MH - Statistics as Topic OTO - NOTNLM OT - Cardiovascular magnetic resonance OT - Electrocardiography OT - Hypertrophic cardiomyopathy OT - Late gadolinium enhancement EDAT- 2013/12/18 06:00 MHDA- 2014/10/02 06:00 CRDT- 2013/12/17 06:00 PHST- 2013/04/12 00:00 [received] PHST- 2013/09/24 00:00 [revised] PHST- 2013/10/25 00:00 [accepted] PHST- 2013/12/17 06:00 [entrez] PHST- 2013/12/18 06:00 [pubmed] PHST- 2014/10/02 06:00 [medline] AID - S0720-048X(13)00582-2 [pii] AID - 10.1016/j.ejrad.2013.10.025 [doi] PST - ppublish SO - Eur J Radiol. 2014 Feb;83(2):297-302. doi: 10.1016/j.ejrad.2013.10.025. Epub 2013 Nov 7.