PMID- 24332937
OWN - NLM
STAT- MEDLINE
DCOM- 20141118
LR  - 20220410
IS  - 1873-460X (Electronic)
IS  - 1056-8727 (Linking)
VI  - 28
IP  - 2
DP  - 2014 Mar-Apr
TI  - Relationship between circulating irisin, renal function and body composition in 
      type 2 diabetes.
PG  - 208-13
LID - S1056-8727(13)00214-6 [pii]
LID - 10.1016/j.jdiacomp.2013.09.011 [doi]
AB  - AIMS: Chronic kidney disease (CKD) secondary to type 2 diabetes mellitus (T2DM) 
      is associated with multifaceted energy dysmetabolism. We aim to study the 
      relationship between renal function, body composition and irisin, the recently 
      identified myokine which is involved in energy regulation, in T2DM. METHODS: 
      Circulating irisin and body composition were measured in 365 T2DM subjects across 
      a wide range of renal function. RESULTS: Circulating irisin was significantly 
      decreased in T2DM with renal insufficiency (77.4 +/- 13.7 ng/ml in T2DM with eGFR >/= 
      60 ml/min/1.73 m(2) versus 72.5 +/- 14.9 ng/ml in those with eGFR<60 ml/min/1.73 
      m(2), p = 0.001) and the reduction in irisin was most pronounced in stage 5 CKD 
      patients. In T2DM with preserved renal function, irisin was correlated with age 
      (r = -0.242, p = 0.001) and pulse pressure (r = -0.188, p = 0.002). Among those 
      with renal insufficiency, irisin was correlated with BMI (r = 0.171, p = 0.022), 
      fat mass (r = 0.191, p = 0.013), percentage of fat mass (r = 0.210, p = 0.007) 
      and eGFR (r = 0.171, p = 0.020). Multivariate linear regression models revealed 
      that variations in circulating irisin were mainly attributable to eGFR and age in 
      T2DM with and without renal impairment, respectively. CONCLUSION: Our 
      observations suggest that the level of circulating irisin may be associated with 
      renal function in T2DM. The role of reduced irisin in energy dysmetabolism in 
      diabetic patients with renal insufficiency deserves further investigation.
CI  - (c) 2014.
FAU - Liu, Jian-Jun
AU  - Liu JJ
AD  - Clinical Research Unit, Khoo Teck Puat Hospital, Republic of Singapore.
FAU - Liu, Sylvia
AU  - Liu S
AD  - Clinical Research Unit, Khoo Teck Puat Hospital, Republic of Singapore.
FAU - Wong, Melvin D S
AU  - Wong MD
AD  - Clinical Research Unit, Khoo Teck Puat Hospital, Republic of Singapore.
FAU - Tan, Clara S H
AU  - Tan CS
AD  - Clinical Research Unit, Khoo Teck Puat Hospital, Republic of Singapore.
FAU - Tavintharan, Subramaniam
AU  - Tavintharan S
AD  - Diabetes Centre, Khoo Teck Puat Hospital, Republic of Singapore; Department of 
      Medicine, Khoo Teck Puat Hospital, Republic of Singapore.
FAU - Sum, Chee Fang
AU  - Sum CF
AD  - Diabetes Centre, Khoo Teck Puat Hospital, Republic of Singapore; Department of 
      Medicine, Khoo Teck Puat Hospital, Republic of Singapore.
FAU - Lim, Su Chi
AU  - Lim SC
AD  - Diabetes Centre, Khoo Teck Puat Hospital, Republic of Singapore; Department of 
      Medicine, Khoo Teck Puat Hospital, Republic of Singapore. Electronic address: 
      lim.su.chi@alexandrahealth.com.sg.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131004
PL  - United States
TA  - J Diabetes Complications
JT  - Journal of diabetes and its complications
JID - 9204583
RN  - 0 (FNDC5 protein, human)
RN  - 0 (Fibronectins)
SB  - IM
MH  - Aged
MH  - *Body Composition
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*complications/*metabolism/physiopathology
MH  - Female
MH  - Fibronectins/*blood
MH  - Glomerular Filtration Rate
MH  - Humans
MH  - Kidney/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Renal Insufficiency, Chronic/etiology/metabolism/physiopathology
OTO - NOTNLM
OT  - Body composition
OT  - Chronic kidney disease
OT  - Diabetic nephropathy
OT  - Irisin
OT  - Type 2 diabetes
EDAT- 2013/12/18 06:00
MHDA- 2014/11/19 06:00
CRDT- 2013/12/17 06:00
PHST- 2013/08/15 00:00 [received]
PHST- 2013/09/25 00:00 [revised]
PHST- 2013/09/26 00:00 [accepted]
PHST- 2013/12/17 06:00 [entrez]
PHST- 2013/12/18 06:00 [pubmed]
PHST- 2014/11/19 06:00 [medline]
AID - S1056-8727(13)00214-6 [pii]
AID - 10.1016/j.jdiacomp.2013.09.011 [doi]
PST - ppublish
SO  - J Diabetes Complications. 2014 Mar-Apr;28(2):208-13. doi: 
      10.1016/j.jdiacomp.2013.09.011. Epub 2013 Oct 4.