PMID- 24333433
OWN - NLM
STAT- MEDLINE
DCOM- 20140310
LR  - 20220331
IS  - 1090-2104 (Electronic)
IS  - 0006-291X (Linking)
VI  - 443
IP  - 2
DP  - 2014 Jan 10
TI  - Forced running exercise attenuates hippocampal neurogenesis impairment and the 
      neurocognitive deficits induced by whole-brain irradiation via the BDNF-mediated 
      pathway.
PG  - 646-51
LID - S0006-291X(13)02088-3 [pii]
LID - 10.1016/j.bbrc.2013.12.031 [doi]
AB  - Cranial radiotherapy induces progressive and debilitating cognitive deficits, 
      particularly in long-term cancer survivors, which may in part be caused by the 
      reduction of hippocampal neurogenesis. Previous studies suggested that voluntary 
      exercise can reduce the cognitive impairment caused by radiation therapy. 
      However, there is no study on the effect of forced wheel exercise and little is 
      known about the molecular mechanisms mediating the effect of exercise. In the 
      present study, we investigated whether the forced running exercise after 
      irradiation had the protective effects of the radiation-induced cognitive 
      impairment. Sixty-four Male Sprague-Dawley rats received a single dose of 20Gy or 
      sham whole-brain irradiation (WBI), behavioral test was evaluated using open 
      field test and Morris water maze at 2months after irradiation. Half of the rats 
      accepted a 3-week forced running exercise before the behavior detection. 
      Immunofluorescence was used to evaluate the changes in hippocampal neurogenesis 
      and Western blotting was used to assess changes in the levels of mature 
      brain-derived neurotrophic factor (BDNF), phosphorylated tyrosine receptor kinase 
      B (TrkB) receptor, protein kinase B (Akt), extracellular signal-regulated kinase 
      (ERK), calcium-calmodulin dependent kinase (CaMKII), cAMP-calcium response 
      element binding protein (CREB) in the BDNF-pCREB signaling. We found forced 
      running exercise significantly prevented radiation-induced cognitive deficits, 
      ameliorated the impairment of hippocampal neurogenesis and attenuated the 
      down-regulation of these proteins. Moreover, exercise also increased behavioral 
      performance, hippocampal neurogenesis and elevated BDNF-pCREB signaling in 
      non-irradiation group. These results suggest that forced running exercise offers 
      a potentially effective treatment for radiation-induced cognitive deficits.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Ji, Jian-feng
AU  - Ji JF
AD  - Department of Radiotherapy and Oncology, The Second Affiliated Hospital of 
      Soochow University, San Xiang Road No. 1055, Suzhou 215004, China.
FAU - Ji, Sheng-jun
AU  - Ji SJ
AD  - Department of Radiotherapy and Oncology, The Second Affiliated Hospital of 
      Soochow University, San Xiang Road No. 1055, Suzhou 215004, China.
FAU - Sun, Rui
AU  - Sun R
AD  - Department of Radiotherapy and Oncology, The Second Affiliated Hospital of 
      Soochow University, San Xiang Road No. 1055, Suzhou 215004, China.
FAU - Li, Kun
AU  - Li K
AD  - Department of Radiotherapy and Oncology, The Second Affiliated Hospital of 
      Soochow University, San Xiang Road No. 1055, Suzhou 215004, China.
FAU - Zhang, Yuan
AU  - Zhang Y
AD  - Department of Radiotherapy and Oncology, The Second Affiliated Hospital of 
      Soochow University, San Xiang Road No. 1055, Suzhou 215004, China.
FAU - Zhang, Li-yuan
AU  - Zhang LY
AD  - Department of Radiotherapy and Oncology, The Second Affiliated Hospital of 
      Soochow University, San Xiang Road No. 1055, Suzhou 215004, China.
FAU - Tian, Ye
AU  - Tian Y
AD  - Department of Radiotherapy and Oncology, The Second Affiliated Hospital of 
      Soochow University, San Xiang Road No. 1055, Suzhou 215004, China. Electronic 
      address: dryetian@hotmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131211
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Brain/*physiopathology/radiation effects
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cognition/*radiation effects
MH  - Cognition Disorders/etiology/pathology/*physiopathology
MH  - Hippocampus/pathology/physiopathology/radiation effects
MH  - Male
MH  - Maze Learning
MH  - Neurogenesis/*radiation effects
MH  - Physical Conditioning, Animal/*adverse effects
MH  - Radiation Dosage
MH  - Radiation Injuries/etiology/pathology/*physiopathology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Signal Transduction/radiation effects
OTO - NOTNLM
OT  - BDNF
OT  - Cognitive impairments
OT  - Exercise
OT  - Radiation
EDAT- 2013/12/18 06:00
MHDA- 2014/03/13 06:00
CRDT- 2013/12/17 06:00
PHST- 2013/11/12 00:00 [received]
PHST- 2013/12/04 00:00 [accepted]
PHST- 2013/12/17 06:00 [entrez]
PHST- 2013/12/18 06:00 [pubmed]
PHST- 2014/03/13 06:00 [medline]
AID - S0006-291X(13)02088-3 [pii]
AID - 10.1016/j.bbrc.2013.12.031 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2014 Jan 10;443(2):646-51. doi: 
      10.1016/j.bbrc.2013.12.031. Epub 2013 Dec 11.