PMID- 24333549
OWN - NLM
STAT- MEDLINE
DCOM- 20141007
LR  - 20161125
IS  - 1879-0712 (Electronic)
IS  - 0014-2999 (Linking)
VI  - 723
DP  - 2014 Jan 15
TI  - Inhibitory effect of Malvidin on TNF-alpha-induced inflammatory response in 
      endothelial cells.
PG  - 67-72
LID - S0014-2999(13)00917-5 [pii]
LID - 10.1016/j.ejphar.2013.11.041 [doi]
AB  - Vascular inflammatory responses are key mediators of endothelial dysfunction that 
      leads to various pathologies in many diseases including atherosclerosis and 
      cancer. The purpose of the study was to investigate the effects and molecular 
      mechanisms of Malvidin, a natural pigment with strong antioxidant activity, on 
      regulating inflammatory response in endothelial cells. Our results showed that 
      tumor necrosis factor-alpha (TNF-alpha) significantly increased the protein or mRNA 
      levels of monocyte chemotactic protein-1 (MCP-1), intercellular adhesion 
      molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1), whereas 
      pretreatment with Malvidin inhibited TNF-alpha-induced increases of MCP-1, ICAM-1, 
      and VCAM-1 production in a concentration-dependent manner. In addition, Malvidin 
      could inhibit degradation of IkappaBalpha and the nuclear translocation of p65, which 
      suggesting the anti-inflammation mechanism of Malvidin by the nuclear factor 
      kappa B (NF-kappaB) pathway. These results indicate the potential role of Malvidin in 
      preventing chronic inflammation in many diseases.
CI  - (c) 2013 Published by Elsevier B.V.
FAU - Huang, Wu-Yang
AU  - Huang WY
AD  - Department of Functional Food and Bio-active Compounds, Institute of Farm Product 
      Processing, Jiangsu Academy of Agricultural Science, Nanjing 210014, PR China.
FAU - Wang, Jian
AU  - Wang J
AD  - Department of Functional Food and Bio-active Compounds, Institute of Farm Product 
      Processing, Jiangsu Academy of Agricultural Science, Nanjing 210014, PR China; 
      College of Food Science and Technology, Nanjing Agricultural University, Nanjing 
      210095, PR China.
FAU - Liu, Ya-Mei
AU  - Liu YM
AD  - National Technical Research Centre of Veterinary Biological Products, Jiangsu 
      Academy of Agricultural Science, Nanjing 210014, PR China.
FAU - Zheng, Qi-Sheng
AU  - Zheng QS
AD  - National Technical Research Centre of Veterinary Biological Products, Jiangsu 
      Academy of Agricultural Science, Nanjing 210014, PR China.
FAU - Li, Chun-Yang
AU  - Li CY
AD  - Department of Functional Food and Bio-active Compounds, Institute of Farm Product 
      Processing, Jiangsu Academy of Agricultural Science, Nanjing 210014, PR China. 
      Electronic address: lichunyang968@hotmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131211
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Anthocyanins)
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Antioxidants)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (I-kappa B Proteins)
RN  - 0 (NF-kappa B)
RN  - 0 (NFKBIA protein, human)
RN  - 0 (RNA, Messenger)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (Vascular Cell Adhesion Molecule-1)
RN  - 10463-84-0 (malvidin)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
RN  - 139874-52-5 (NF-KappaB Inhibitor alpha)
SB  - IM
MH  - Anthocyanins/*pharmacology
MH  - Anti-Inflammatory Agents/*pharmacology
MH  - Antioxidants/*pharmacology
MH  - Cells, Cultured
MH  - Chemokine CCL2/genetics/metabolism
MH  - Human Umbilical Vein Endothelial Cells/*drug effects/metabolism
MH  - Humans
MH  - I-kappa B Proteins/metabolism
MH  - Intercellular Adhesion Molecule-1/genetics/metabolism
MH  - NF-KappaB Inhibitor alpha
MH  - NF-kappa B/metabolism
MH  - RNA, Messenger/metabolism
MH  - Tumor Necrosis Factor-alpha/*antagonists & inhibitors
MH  - Vascular Cell Adhesion Molecule-1/metabolism
OTO - NOTNLM
OT  - Adhesion molecule
OT  - Anti-inflammation
OT  - Endothelial cells
OT  - Malvidin
OT  - NF-kappaB pathway
OT  - TNF-alpha
EDAT- 2013/12/18 06:00
MHDA- 2014/10/08 06:00
CRDT- 2013/12/17 06:00
PHST- 2013/07/23 00:00 [received]
PHST- 2013/11/22 00:00 [revised]
PHST- 2013/11/22 00:00 [accepted]
PHST- 2013/12/17 06:00 [entrez]
PHST- 2013/12/18 06:00 [pubmed]
PHST- 2014/10/08 06:00 [medline]
AID - S0014-2999(13)00917-5 [pii]
AID - 10.1016/j.ejphar.2013.11.041 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 2014 Jan 15;723:67-72. doi: 10.1016/j.ejphar.2013.11.041. Epub 
      2013 Dec 11.