PMID- 2433378
OWN - NLM
STAT- MEDLINE
DCOM- 19870303
LR  - 20190903
IS  - 0022-0736 (Print)
IS  - 0022-0736 (Linking)
VI  - 19
IP  - 1
DP  - 1986 Jan
TI  - Effects of oral diltiazem on ventricular premature contractions.
PG  - 59-66
AB  - The effects of oral diltiazem (90-180 mg/day for four weeks) on ventricular 
      premature contractions (VPCs) were studied in 16 patients with frequent VPCs 
      using 24-hour ambulatory ECG recordings. VPC frequency was evaluated as a 
      function of underlying heart rate. Plots of VPC frequency vs. heart rate were 
      made at 1-beat/min intervals for all heart rates recorded for at least five 
      minutes during 24 hours. Patterns of correlation between VPC frequency and heart 
      rate observed before diltiazem therapy included: 1) a relatively linear increase 
      in VPCs with heart rate (positive correlation) in ten patients, 2) a linear 
      decrease (negative correlation) in one patient, and 3) an increase at low heart 
      rates and a decrease at high heart rates (bidirectional correlation) in five 
      patients. Diltiazem significantly reduced the mean VPC frequency per 24 hours for 
      patients with a positive correlation, but induced no significant change for 
      patients with a negative or a bidirectional correlation. At the 65% level of VPC 
      reduction, diltiazem was effective in eight of ten patients with a positive 
      correlation but was not effective in the six patients with other correlations (p 
      less than 0.01). These results suggest that an evaluation of VPC frequency as a 
      function of heart rate predicts the response of VPCs to diltiazem.
FAU - Ito, M
AU  - Ito M
FAU - Maeda, Y
AU  - Maeda Y
FAU - Arita, M
AU  - Arita M
FAU - Ito, S
AU  - Ito S
FAU - Saikawa, T
AU  - Saikawa T
FAU - Omura, I
AU  - Omura I
FAU - Fujino, T
AU  - Fujino T
FAU - Fukumoto, T
AU  - Fukumoto T
FAU - Kikuchi, Y
AU  - Kikuchi Y
FAU - Yamada, K
AU  - Yamada K
AU  - et al.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Electrocardiol
JT  - Journal of electrocardiology
JID - 0153605
RN  - EE92BBP03H (Diltiazem)
SB  - IM
MH  - Administration, Oral
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Cardiac Complexes, Premature/*drug therapy/physiopathology
MH  - Child
MH  - Diltiazem/administration & dosage/*therapeutic use
MH  - Electrocardiography
MH  - Female
MH  - Heart Rate/drug effects
MH  - Heart Ventricles
MH  - Humans
MH  - Male
MH  - Middle Aged
EDAT- 1986/01/01 00:00
MHDA- 1986/01/01 00:01
CRDT- 1986/01/01 00:00
PHST- 1986/01/01 00:00 [pubmed]
PHST- 1986/01/01 00:01 [medline]
PHST- 1986/01/01 00:00 [entrez]
AID - 10.1016/s0022-0736(86)80008-5 [doi]
PST - ppublish
SO  - J Electrocardiol. 1986 Jan;19(1):59-66. doi: 10.1016/s0022-0736(86)80008-5.