PMID- 24334024 OWN - NLM STAT- MEDLINE DCOM- 20141104 LR - 20211021 IS - 1873-2747 (Electronic) IS - 0361-9230 (Print) IS - 0361-9230 (Linking) VI - 101 DP - 2014 Feb TI - Periodic maternal deprivation may modulate offspring anxiety-like behavior through mechanisms involving neuroplasticity in the amygdala. PG - 7-11 LID - S0361-9230(13)00194-9 [pii] LID - 10.1016/j.brainresbull.2013.12.005 [doi] AB - Maternal care has been shown to affect the development of behavioral and endocrine systems. In rats, periodic maternal deprivation (PMD) serves as an early life stressor that directly influences maternal care by promoting more pup-directed behaviors in stressed dams. To further assess the qualities of PMD that may ameliorate long-term anxiety effects in trait anxiety animals, we coded behaviors across lactation (postnatal day (PND) 5, 16, 21) in dams phenotyped as high (HAn) and low-anxiety (LAn). We assessed anxiety-like behavior in male offspring using the elevated plus maze (EPM), focusing on percent open arm (%OA) time and latency to enter OA (OA LAT) as measures of anxiety-like behavior. Finally, we examined the brains of representative male pups to determine if the stress-related protein brain-derived neurotrophic factor (BDNF) might show persistent changes in the amygdala. Dams phenotyped as HAn had lower %OA time and longer OA LAT relative to dams designated as LAn. During PMD, HAn dams had higher incidences of licking-grooming (L/G) and more pup-directed behaviors on PND 5 and 16 compared to LAn dams. Further, as adults, HAn male offspring exhibited less anxiety traits than their maternal line with greater %OA time and %OA entries relative to LAn. HAn offspring showed markedly more BDNF immunoreacted cells in the amygdala than LAn. The combination of these findings suggests that the mild stressor, PMD alters anxiety-like behavior in offspring likely by influencing HAn dams' L/G activity and altering stress related proteins in the amygdala. CI - Copyright (c) 2013 Elsevier Inc. All rights reserved. FAU - Berman, Ariel Kupfer AU - Berman AK AD - Department of Psychology, Brandeis University, Waltham, MA 02454, USA. FAU - Lott, Rhonda B AU - Lott RB AD - Developmental and Brain Sciences Program, Department of Psychology, University of Massachusetts Boston, 100 Morrissey Boulevard, Boston, MA 02115, USA. FAU - Donaldson, S Tiffany AU - Donaldson ST AD - Developmental and Brain Sciences Program, Department of Psychology, University of Massachusetts Boston, 100 Morrissey Boulevard, Boston, MA 02115, USA. Electronic address: Tiffany.Donaldson@umb.edu. LA - eng GR - P20 MD002290/MD/NIMHD NIH HHS/United States PT - Journal Article DEP - 20131212 PL - United States TA - Brain Res Bull JT - Brain research bulletin JID - 7605818 RN - 0 (Brain-Derived Neurotrophic Factor) SB - IM MH - Amygdala/*physiopathology MH - Animals MH - Anxiety/*physiopathology MH - Brain-Derived Neurotrophic Factor/*metabolism MH - Female MH - Grooming MH - Immunohistochemistry MH - Lactation MH - Male MH - Maternal Behavior/physiology MH - *Maternal Deprivation MH - Maze Learning MH - Neuronal Plasticity/*physiology MH - Neuropsychological Tests MH - Rats MH - Rats, Long-Evans MH - Task Performance and Analysis MH - Time Factors PMC - PMC3939038 MID - NIHMS549536 OTO - NOTNLM OT - BDNF OT - Elevated plus maze OT - High anxiety OT - Licking/grooming OT - Maternal separation EDAT- 2013/12/18 06:00 MHDA- 2014/11/05 06:00 PMCR- 2015/02/01 CRDT- 2013/12/17 06:00 PHST- 2013/08/14 00:00 [received] PHST- 2013/12/03 00:00 [revised] PHST- 2013/12/05 00:00 [accepted] PHST- 2013/12/17 06:00 [entrez] PHST- 2013/12/18 06:00 [pubmed] PHST- 2014/11/05 06:00 [medline] PHST- 2015/02/01 00:00 [pmc-release] AID - S0361-9230(13)00194-9 [pii] AID - 10.1016/j.brainresbull.2013.12.005 [doi] PST - ppublish SO - Brain Res Bull. 2014 Feb;101:7-11. doi: 10.1016/j.brainresbull.2013.12.005. Epub 2013 Dec 12.