PMID- 24334166
OWN - NLM
STAT- MEDLINE
DCOM- 20140928
LR  - 20180816
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 559
DP  - 2014 Jan 24
TI  - Urinary BDNF-to-creatinine ratio is associated with aerobic fitness.
PG  - 169-73
LID - S0304-3940(13)01076-8 [pii]
LID - 10.1016/j.neulet.2013.12.004 [doi]
AB  - Circulating levels of brain-derived neurotrophic factor (BDNF) are known to be 
      affected by aerobic exercise. As the previous research focus in humans has been 
      to examine peripheral BDNF levels through blood, serum, and platelet assay, the 
      present study investigated the association between basal urinary BDNF 
      concentration and indices of aerobic fitness in a sample of young adults (n=52). 
      Aerobic fitness was evaluated with self-report of exercise habits and heart rate 
      (HR) assessment during a sub-maximal Step Test. BDNF concentration was determined 
      by enzyme-linked immunosorbent assay and adjusted for creatinine. Results 
      indicated that the basal BDNFlog/creatinine ratio was positively associated with 
      greater frequency of exercise and, during aerobic challenge, a quicker rise in HR 
      upon exercise, lower peak HR during exercise, and lower HR during the recovery 
      period, each indicative of enhanced fitness. These results highlight the utility 
      of urine capture as a non-invasive technique to assess for exercise-mediated 
      changes in peripheral BDNF.
CI  - Copyright (c) 2013 Elsevier Ireland Ltd. All rights reserved.
FAU - Collins, Larisa R
AU  - Collins LR
AD  - Program in Neuroscience, Department of Psychology, Bates College, 4 Andrews Road, 
      Lewiston, ME 04240, USA. Electronic address: lrcollins@mgh.harvard.edu.
FAU - Koven, Nancy S
AU  - Koven NS
AD  - Program in Neuroscience, Department of Psychology, Bates College, 4 Andrews Road, 
      Lewiston, ME 04240, USA. Electronic address: nkoven@bates.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131212
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Adolescent
MH  - Biomarkers/urine
MH  - Brain-Derived Neurotrophic Factor/*urine
MH  - Creatinine/*urine
MH  - Exercise/*physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Physical Fitness/*physiology
MH  - *Self Report
MH  - Young Adult
OTO - NOTNLM
OT  - Aerobic fitness
OT  - BDNF
OT  - Brain-derived neurotrophic factor
OT  - ELISA
OT  - Exercise
OT  - HR
OT  - Peripheral biomarker
OT  - beats-per-minute
OT  - bpm
OT  - brain-derived neurotrophic factor
OT  - enzyme-linked immunosorbent assay
OT  - heart rate
EDAT- 2013/12/18 06:00
MHDA- 2014/10/01 06:00
CRDT- 2013/12/17 06:00
PHST- 2013/10/29 00:00 [received]
PHST- 2013/11/25 00:00 [revised]
PHST- 2013/12/04 00:00 [accepted]
PHST- 2013/12/17 06:00 [entrez]
PHST- 2013/12/18 06:00 [pubmed]
PHST- 2014/10/01 06:00 [medline]
AID - S0304-3940(13)01076-8 [pii]
AID - 10.1016/j.neulet.2013.12.004 [doi]
PST - ppublish
SO  - Neurosci Lett. 2014 Jan 24;559:169-73. doi: 10.1016/j.neulet.2013.12.004. Epub 
      2013 Dec 12.