PMID- 24334784
OWN - NLM
STAT- MEDLINE
DCOM- 20150402
LR  - 20190201
IS  - 2384-8553 (Electronic)
IS  - 0021-2571 (Linking)
VI  - 49
IP  - 4
DP  - 2013
TI  - NGF and BDNF long-term variations in the thyroid, testis and adrenal glands of a 
      mouse model of fetal alcohol spectrum disorders.
PG  - 383-90
LID - 10.4415/ANN_13_04_11 [doi]
AB  - OBJECTIVES: Fetal Alcohol Spectrum Disorders (FASD) due to prenatal ethanol 
      consumption may induce long-lasting changes to the newborns affecting also the 
      endocrine system and the nerve growth factor (NGF) and brain derived neurotrophic 
      factor (BDNF) signaling. Thus the aim of this study was to investigate in the 
      thyroid, testis and adrenal glands of a FASD mouse model the long-lasting effects 
      of ethanol exposure during pregnancy and lactation on NGF and BDNF and their main 
      receptors, TrkA and TrkB, including their phosphorylated patterns. METHODS: We 
      used aged male CD-1 mice early exposed to ethanol solution or red wine at same 
      ethanol concentration (11% vol). RESULTS: We found elevations in NGF and BDNF in 
      the thyroid of aged mice exposed to ethanol solution only but not in the red wine 
      group. In the testis NGF resulted to be increased only in the ethanol solution 
      group. In the adrenal glands data showed an elevation in NGF in both the ethanol 
      solution group and red wine. No changes in TrkA, TrkB, phospho-TrkA and 
      phospho-TrkB were revealed in all tissues examined. CONCLUSIONS: Early 
      administration of ethanol may induce long-lasting changes in the mouse thyroid, 
      testis and adrenal glands at NGF and BDNF levels.
FAU - Ceccanti, Mauro
AU  - Ceccanti M
AD  - Centro Riferimento Alcologico Regione Lazio, Sapienza Universita di Roma, Rome, 
      Italy.
FAU - De Nicolo, Sara
AU  - De Nicolo S
FAU - Mancinelli, Rosanna
AU  - Mancinelli R
FAU - Chaldakov, George
AU  - Chaldakov G
FAU - Carito, Valentina
AU  - Carito V
FAU - Ceccanti, Marco
AU  - Ceccanti M
FAU - Laviola, Giovanni
AU  - Laviola G
FAU - Tirassa, Paola
AU  - Tirassa P
FAU - Fiore, Marco
AU  - Fiore M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Italy
TA  - Ann Ist Super Sanita
JT  - Annali dell'Istituto superiore di sanita
JID - 7502520
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Adrenal Glands/*metabolism
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Female
MH  - Fetal Alcohol Spectrum Disorders/*metabolism
MH  - Male
MH  - Mice
MH  - Nerve Growth Factor/*metabolism
MH  - Pregnancy
MH  - Testis/*metabolism
MH  - Thyroid Gland/*metabolism
EDAT- 2013/12/18 06:00
MHDA- 2015/04/04 06:00
CRDT- 2013/12/17 06:00
PHST- 2013/12/17 06:00 [entrez]
PHST- 2013/12/18 06:00 [pubmed]
PHST- 2015/04/04 06:00 [medline]
AID - 10.4415/ANN_13_04_11 [doi]
PST - ppublish
SO  - Ann Ist Super Sanita. 2013;49(4):383-90. doi: 10.4415/ANN_13_04_11.