PMID- 24334967
OWN - NLM
STAT- MEDLINE
DCOM- 20141022
LR  - 20140319
IS  - 1423-0267 (Electronic)
IS  - 0030-3755 (Linking)
VI  - 231
IP  - 3
DP  - 2014
TI  - Comparison of normal- and high-tension glaucoma: nerve fiber layer and optic 
      nerve head damage.
PG  - 160-5
LID - 10.1159/000355326 [doi]
AB  - PURPOSE: The aim of this study was to investigate differences in the nerve fiber 
      layer and glaucoma-induced structural optic nerve head (ONH) damage in patients 
      with normal- (NTG) and high-tension (HTG) glaucoma. METHODS: In this 
      retrospective pair-matched comparative study, 22 NTG and 22 HTG eyes were matched 
      according to the same glaucomatous damage based on rim volume, rim area and disk 
      size, as measured by Heidelberg retinal tomography (HRT III). Visual fields (VF) 
      were assessed by Humphrey perimetry, and nerve fiber layer thickness was 
      determined both by scanning laser polarimetry (GDxVCC) and spectral-domain 
      optical coherence tomography (SD-OCT). Comparisons of all measured parameters 
      were made between NTG and HTG groups. RESULTS: Based on HRT results, both NTG and 
      HTG eyes displayed comparable structural damage to the ONH (NTG/HTG, mean: disk 
      area, 2.30/2.31 mm(2), p = 0.942; rim area, 1.02/0.86 mm(2), p = 0.082; rim 
      volume, 0.19/0.17 mm(3), p = 0.398). NTG eyes had significantly less VF damage 
      than HTG eyes (NTG/HTG, mean deviation: -4.23/-12.12 dB, p = 0.002; pattern 
      standard deviation: 5.39/8.23 dB, p = 0.022). The inferior nerve fiber layer of 
      NTG patients was significantly thicker than that of HTG patients (NTG/HTG, mean: 
      GDx inferior: 53.5/46.3 microm, p = 0.046). SD-OCT revealed a significantly thicker 
      nerve fiber in NTG compared with HTG patients in all quadrants (NTG/HTG, total 
      mean: 72.72/58.45 microm, p = 0.002). CONCLUSION: At comparable glaucomatous stages, 
      nerve fiber loss was more advanced in HTG patients compared with NTG patients.
FAU - Hantzschel, Janek
AU  - Hantzschel J
AD  - Department of Ophthalmology, Carl Gustav Carus University Hospital, Dresden, 
      Germany.
FAU - Terai, Naim
AU  - Terai N
FAU - Furashova, Olga
AU  - Furashova O
FAU - Pillunat, Karin
AU  - Pillunat K
FAU - Pillunat, Lutz E
AU  - Pillunat LE
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20131207
PL  - Switzerland
TA  - Ophthalmologica
JT  - Ophthalmologica. Journal international d'ophtalmologie. International journal of 
      ophthalmology. Zeitschrift fur Augenheilkunde
JID - 0054655
SB  - IM
MH  - Female
MH  - Humans
MH  - Intraocular Pressure
MH  - Low Tension Glaucoma/*diagnosis
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers/*pathology
MH  - Ocular Hypertension/*diagnosis
MH  - Optic Disk/*pathology
MH  - Optic Nerve Diseases/*diagnosis
MH  - Retrospective Studies
MH  - Scanning Laser Polarimetry
MH  - Tomography, Optical Coherence
MH  - Tonometry, Ocular
MH  - Visual Field Tests
MH  - Visual Fields
EDAT- 2013/12/18 06:00
MHDA- 2014/10/23 06:00
CRDT- 2013/12/17 06:00
PHST- 2013/04/02 00:00 [received]
PHST- 2013/08/17 00:00 [accepted]
PHST- 2013/12/17 06:00 [entrez]
PHST- 2013/12/18 06:00 [pubmed]
PHST- 2014/10/23 06:00 [medline]
AID - 000355326 [pii]
AID - 10.1159/000355326 [doi]
PST - ppublish
SO  - Ophthalmologica. 2014;231(3):160-5. doi: 10.1159/000355326. Epub 2013 Dec 7.