PMID- 24335635
OWN - NLM
STAT- MEDLINE
DCOM- 20140926
LR  - 20131216
IS  - 1528-1159 (Electronic)
IS  - 0362-2436 (Linking)
VI  - 38
IP  - 26
DP  - 2013 Dec 15
TI  - Hyperbaric oxygen alleviates experimental (spinal cord) injury by downregulating 
      HMGB1/NF-kappaB expression.
PG  - E1641-8
LID - 10.1097/BRS.0000000000000005 [doi]
AB  - STUDY DESIGN: We presented an insight into the effect of hyperbaric oxygen (HBO) 
      on spinal cord injury (SCI), aiming to uncover the dynamics of high-mobility 
      group protein B1 (HMGB1) and nuclear factor kappaB (NF-kappaB) after HBO intervention in 
      rats with acute SCI. OBJECTIVE: Prognosis of SCI is directly linked with the 
      control of secondary injury, in which the inflammatory response plays a leading 
      role. HBO therapy can reduce this secondary damage to the spinal cord. We used an 
      animal model to characterize the therapeutic effect of HBO on SCI. SUMMARY OF 
      BACKGROUND DATA: A growing number of studies have confirmed that HBO has 
      gradually become an indispensable element after SCI in reducing neurological 
      disorders, and improving the physical function and quality of life of patients. 
      The role of HBO in the process of HMGB1/NF-kappaB-related secondary inflammatory 
      responses in SCI has yet to be characterized. METHODS: Rats were randomly 
      categorized into sham, sham + HBO, SCI, and SCI + HBO groups. The expression 
      levels of HMGB1 and NF-kappaB were measured at days 1, 3, 7, and 14 after SCI. 
      RESULTS: After SCI, significant increases in mRNA and protein expression were 
      observed for both HMGB1 and NF-kappaB (P< 0.01) compared with sham group. HMGB1 mRNA 
      and protein expression levels were decreased after HBO intervention. The 
      decreases were significant at days 7 and 14 (P< 0.05) post-HBO. In the SCI + HBO 
      group, the significant decreases in NF-kappaB mRNA and protein expression levels were 
      also observed at days 3, 7, and 14 (P< 0.05). After HBO intervention, a 
      significant increase was seen in the Basso, Beattie, and Bresnahan score at days 
      7 and 14 (P< 0.05). CONCLUSION: HBO intervention may reduce the secondary damage 
      of SCI caused by inflammatory responses via downregulating the expression of 
      HMGB1/NF-kappaB, and promoting the repair of neurological function. LEVEL OF 
      EVIDENCE: N/A.
FAU - Yang, Jing
AU  - Yang J
AD  - *Department of Hyperbaric Oxygen, Beijing Chao-yang Hospital, Capital Medical 
      University, Beijing, China daggerDepartment of Orthopaedics, Shen Zhou Hospital 
      Affiliated to Shenyang Medical College, Shenyang, China double daggerDepartment of Hyperbaric 
      Oxygen, Civil Aviation General Hospital, Beijing, China; and  section signDepartment of 
      Orthopaedics, Beijing Chao-yang Hospital, Capital Medical University, Beijing, 
      China.
FAU - Liu, Xuehua
AU  - Liu X
FAU - Zhou, Yi
AU  - Zhou Y
FAU - Wang, Guozhong
AU  - Wang G
FAU - Gao, Chunjin
AU  - Gao C
FAU - Su, Qingjun
AU  - Su Q
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Spine (Phila Pa 1976)
JT  - Spine
JID - 7610646
RN  - 0 (HMGB1 Protein)
RN  - 0 (NF-kappa B)
SB  - IM
MH  - Animals
MH  - Blotting, Western
MH  - *Down-Regulation
MH  - HMGB1 Protein/genetics/*metabolism
MH  - Hyperbaric Oxygenation/*methods
MH  - Immunohistochemistry
MH  - Motor Activity
MH  - NF-kappa B/genetics/*metabolism
MH  - Random Allocation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Spinal Cord Injuries/genetics/metabolism/*therapy
MH  - Time Factors
EDAT- 2013/12/18 06:00
MHDA- 2014/09/27 06:00
CRDT- 2013/12/17 06:00
PHST- 2013/12/17 06:00 [entrez]
PHST- 2013/12/18 06:00 [pubmed]
PHST- 2014/09/27 06:00 [medline]
AID - 00007632-201312150-00004 [pii]
AID - 10.1097/BRS.0000000000000005 [doi]
PST - ppublish
SO  - Spine (Phila Pa 1976). 2013 Dec 15;38(26):E1641-8. doi: 
      10.1097/BRS.0000000000000005.