PMID- 24336590
OWN - NLM
STAT- MEDLINE
DCOM- 20151019
LR  - 20211021
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 3
DP  - 2013 Dec 12
TI  - Infrared laser pulse triggers increased singlet oxygen production in tumour 
      cells.
PG  - 3484
LID - 10.1038/srep03484 [doi]
LID - 3484
AB  - Photodynamic therapy (PDT) is a technique developed to treat the ever-increasing 
      global incidence of cancer. This technique utilises singlet oxygen ((1)O2) 
      generation via a laser excited photosensitiser (PS) to kill cancer cells. 
      However, prolonged sensitivity to intensive light (6-8 weeks for lung cancer), 
      relatively low tissue penetration by activating light (630 nm up to 4 mm), and 
      the cost of PS administration can limit progressive PDT applications. The 
      development of quantum-dot laser diodes emitting in the highest absorption region 
      (1268 nm) of triplet oxygen ((3)O2) presents the possibility of inducing 
      apoptosis in tumour cells through direct (3)O2 --> (1)O2 transition. Here we 
      demonstrate that a single laser pulse triggers dose-dependent (1)O2 generation in 
      both normal keratinocytes and tumour cells and show that tumour cells yield the 
      highest (1)O2 far beyond the initial laser pulse exposure. Our modelling and 
      experimental results support the development of direct infrared (IR) 
      laser-induced tumour treatment as a promising approach in tumour PDT.
FAU - Sokolovski, S G
AU  - Sokolovski SG
AD  - Photonics and Nanoscience Group, School of Engineering, Physics and Mathematics, 
      University of Dundee, Dundee DD1 4HN, UK.
FAU - Zolotovskaya, S A
AU  - Zolotovskaya SA
AD  - Photonics and Nanoscience Group, School of Engineering, Physics and Mathematics, 
      University of Dundee, Dundee DD1 4HN, UK.
FAU - Goltsov, A
AU  - Goltsov A
AD  - Centre for Research in Informatics and Systems Pathology (CRISP), University of 
      Abertay Dundee, DD1 1HG, UK.
FAU - Pourreyron, C
AU  - Pourreyron C
AD  - Division of Cancer Research, Medical Research Institute, Ninewells Hospital and 
      Medical School, University of Dundee, Dundee, DD1 9SY, UK.
FAU - South, A P
AU  - South AP
AD  - Division of Cancer Research, Medical Research Institute, Ninewells Hospital and 
      Medical School, University of Dundee, Dundee, DD1 9SY, UK.
FAU - Rafailov, E U
AU  - Rafailov EU
AD  - Photonics and Nanoscience Group, School of Engineering, Physics and Mathematics, 
      University of Dundee, Dundee DD1 4HN, UK.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131212
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Reactive Oxygen Species)
RN  - 0 (Solutions)
RN  - 17778-80-2 (Singlet Oxygen)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Calcium/metabolism
MH  - Cell Death/radiation effects
MH  - Cell Line, Tumor
MH  - Humans
MH  - Infrared Rays/*adverse effects
MH  - Lasers/*adverse effects
MH  - Light
MH  - Neoplasms/*metabolism
MH  - Oxidation-Reduction
MH  - Oxidative Stress
MH  - Reactive Oxygen Species/metabolism
MH  - Singlet Oxygen/*metabolism
MH  - Solutions/chemistry
PMC - PMC3860013
EDAT- 2013/12/18 06:00
MHDA- 2015/10/20 06:00
PMCR- 2013/12/12
CRDT- 2013/12/17 06:00
PHST- 2013/02/20 00:00 [received]
PHST- 2013/11/25 00:00 [accepted]
PHST- 2013/12/17 06:00 [entrez]
PHST- 2013/12/18 06:00 [pubmed]
PHST- 2015/10/20 06:00 [medline]
PHST- 2013/12/12 00:00 [pmc-release]
AID - srep03484 [pii]
AID - 10.1038/srep03484 [doi]
PST - epublish
SO  - Sci Rep. 2013 Dec 12;3:3484. doi: 10.1038/srep03484.