PMID- 24337587
OWN - NLM
STAT- MEDLINE
DCOM- 20140826
LR  - 20131223
IS  - 1791-3004 (Electronic)
IS  - 1791-2997 (Linking)
VI  - 9
IP  - 2
DP  - 2014 Feb
TI  - beta-catenin mediates the inflammatory cytokine expression induced by the Der p 1 
      house dust mite allergen.
PG  - 633-8
LID - 10.3892/mmr.2013.1852 [doi]
AB  - The modulations of beta-catenin were analyzed during the inflammatory response 
      induced by the Der p 1 house dust mite allergen. Der p 1 induced the 
      dose-dependent expression of inflammatory cytokines, including interleukin 
      (IL)-6, IL-8, monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis 
      factor-alpha (TNF-alpha) in THP-1 human monocytic cells. The mRNA expression levels of 
      beta-catenin were not altered, however protein levels increased following Der p 1 
      treatment, demonstrating that beta-catenin was modulated by post-transcriptional 
      processes. It was also revealed that nuclear beta-catenin levels were significantly 
      increased while cytoplasmic beta-catenin levels were reduced, which demonstrated the 
      nuclear translocation of beta-catenin by the Der p 1 allergen. Glycogen synthase 
      kinase 3beta (GSK3beta), a regulator of beta-catenin stability, was demonstrated to be 
      phosphorylated following Der p 1 treatment. When beta-catenin was knocked down by 
      the transfection of its small interfering RNA (siRNA), inflammatory cytokine 
      expression as well as nuclear factor-kappaB (NF-kappaB) activity, which were induced by 
      Der p 1 treatment, were all significantly reduced. The results demonstrated that 
      Der p 1-induced inflammatory responses were mediated by beta-catenin.
FAU - Jang, Jaewoong
AU  - Jang J
AD  - Department of Microbiology, School of Medicine, Chung‑Ang University, Seoul 
      156-756, Republic of Korea.
FAU - Ha, Jong-Hyeok
AU  - Ha JH
AD  - Department of Microbiology, School of Medicine, Chung‑Ang University, Seoul 
      156-756, Republic of Korea.
FAU - Kim, Seok-Min
AU  - Kim SM
AD  - School of Mechanical Engineering, Chung‑Ang University, Seoul 156-756, Republic 
      of Korea.
FAU - Kim, Wonyong
AU  - Kim W
AD  - Department of Microbiology, School of Medicine, Chung‑Ang University, Seoul 
      156-756, Republic of Korea.
FAU - Kim, Kijeong
AU  - Kim K
AD  - Department of Microbiology, School of Medicine, Chung‑Ang University, Seoul 
      156-756, Republic of Korea.
FAU - Chung, Sang-In
AU  - Chung SI
AD  - Department of Microbiology, School of Medicine, Chung‑Ang University, Seoul 
      156-756, Republic of Korea.
FAU - Yoon, Yoosik
AU  - Yoon Y
AD  - Department of Microbiology, School of Medicine, Chung‑Ang University, Seoul 
      156-756, Republic of Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131210
PL  - Greece
TA  - Mol Med Rep
JT  - Molecular medicine reports
JID - 101475259
RN  - 0 (Antigens, Dermatophagoides)
RN  - 0 (Arthropod Proteins)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Interleukin-6)
RN  - 0 (Interleukin-8)
RN  - 0 (RNA, Small Interfering)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (beta Catenin)
RN  - EC 3.4.22.- (Cysteine Endopeptidases)
RN  - EC 3.4.22.- (Dermatophagoides pteronyssinus antigen p 1)
SB  - IM
MH  - Animals
MH  - Antigens, Dermatophagoides/administration & dosage/*immunology
MH  - Arthropod Proteins/*administration & dosage
MH  - Chemokine CCL2/immunology
MH  - Cysteine Endopeptidases/*administration & dosage
MH  - Gene Expression Regulation/immunology
MH  - Humans
MH  - Interleukin-6/immunology
MH  - Interleukin-8/immunology
MH  - Pyroglyphidae/immunology
MH  - RNA, Small Interfering
MH  - Signal Transduction/*immunology
MH  - Tumor Necrosis Factor-alpha/immunology
MH  - beta Catenin/immunology/*metabolism
EDAT- 2013/12/18 06:00
MHDA- 2014/08/27 06:00
CRDT- 2013/12/17 06:00
PHST- 2013/06/14 00:00 [received]
PHST- 2013/12/06 00:00 [accepted]
PHST- 2013/12/17 06:00 [entrez]
PHST- 2013/12/18 06:00 [pubmed]
PHST- 2014/08/27 06:00 [medline]
AID - 10.3892/mmr.2013.1852 [doi]
PST - ppublish
SO  - Mol Med Rep. 2014 Feb;9(2):633-8. doi: 10.3892/mmr.2013.1852. Epub 2013 Dec 10.