PMID- 24338584
OWN - NLM
STAT- MEDLINE
DCOM- 20141021
LR  - 20171206
IS  - 1724-6016 (Electronic)
IS  - 1120-6721 (Linking)
VI  - 24
IP  - 4
DP  - 2014 Jul-Aug
TI  - Photoreceptor layer changes overlying drusen in eyes with age-related macular 
      degeneration associated with vitreomacular traction.
PG  - 582-92
LID - 10.5301/ejo.5000412 [doi]
AB  - PURPOSE: To investigate by spectral-domain optical coherence tomography (SD-OCT) 
      changes of photoreceptor layers over drusen in cases of dry type age-related 
      macular degeneration associated with vitreomacular traction (VMT). METHODS: 
      Clinical examination, fluorescein angiography, fundus photography, and SD-OCT 
      data were retrospectively studied for a consecutive series of 27 patients with 
      drusen, pseudodrusen, and VMT. Control groups of 32 patients with VMT without 
      drusen and 34 patients with drusen and pseudodrusen without VMT were also 
      studied. RESULTS: The examination revealed disruption of the line corresponding 
      to the inner segment ellipsoid (ISel), previously called inner segment/outer 
      segment junction, of photoreceptor layer, and development of cystoid edema in 
      signi fi cantly higher incidence in VMT associated with drusen group. 22 out of 32 
      eyes with VMT and drusen (68.75%) had disrupted ISel, compared to 8 out of 37 
      (21.6%) control eyes with drusen only and to 12 out of 37 (32.4%) control eyes 
      with VMT only. Chi-square analysis showed significant association between drusen 
      and pseudodrusen on fovea, VMT, and localization of ISel disruption. The changes 
      of the ISel were mainly found in the area that corresponded to VMT. The SD-OCT 
      revealed drusen throughout the macula and discontinuation of ISel only in the 
      fovea in 4 of 32 (12.5%) eyes with VMT, whereas none of 37 control eyes with 
      drusen only had similar appearance. CONCLUSIONS: The drusen in association with 
      the cystoid macular edema induced by vitreous traction contribute to the 
      photoreceptor layer defect overlying drusen in the fovea. In addition, the number 
      of drusen and pseudodrusen was increased in the area of the vitreous traction 
      compared to the peripheral retina.
FAU - Theodossiadis, Panagiotis G
AU  - Theodossiadis PG
AD  - 2nd Department of Ophthalmology, "Attikon" University Hospital, University of 
      Athens, Athens - Greece.
FAU - Theodoropoulou, Sofia
AU  - Theodoropoulou S
FAU - Stamatiou, Polixeni
AU  - Stamatiou P
FAU - Datseris, Ioannis
AU  - Datseris I
FAU - Theodossiadis, George P
AU  - Theodossiadis GP
LA  - eng
PT  - Journal Article
DEP - 20131212
PL  - United States
TA  - Eur J Ophthalmol
JT  - European journal of ophthalmology
JID - 9110772
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Fluorescein Angiography
MH  - Geographic Atrophy/*complications
MH  - Humans
MH  - Macular Edema/diagnosis/*etiology
MH  - Male
MH  - Photoreceptor Cells, Vertebrate/*pathology
MH  - Retinal Diseases/*complications
MH  - Retinal Drusen/diagnosis/*etiology
MH  - Retrospective Studies
MH  - Tissue Adhesions
MH  - Tomography, Optical Coherence/methods
MH  - Vitreous Body/*pathology
EDAT- 2013/12/18 06:00
MHDA- 2014/10/22 06:00
CRDT- 2013/12/17 06:00
PHST- 2013/11/24 00:00 [accepted]
PHST- 2013/12/17 06:00 [entrez]
PHST- 2013/12/18 06:00 [pubmed]
PHST- 2014/10/22 06:00 [medline]
AID - 2FAC0D50-E4A4-40E1-9197-E50DA6916E21 [pii]
AID - 10.5301/ejo.5000412 [doi]
PST - ppublish
SO  - Eur J Ophthalmol. 2014 Jul-Aug;24(4):582-92. doi: 10.5301/ejo.5000412. Epub 2013 
      Dec 12.