PMID- 24339409
OWN - NLM
STAT- MEDLINE
DCOM- 20140717
LR  - 20211021
IS  - 2151-4658 (Electronic)
IS  - 2151-464X (Linking)
VI  - 66
IP  - 6
DP  - 2014 Jun
TI  - Value of questionnaire-based screening as a proxy for neurocognitive testing in 
      childhood-onset systemic lupus erythematosus.
PG  - 943-8
AB  - OBJECTIVE: To investigate the utility of questionnaire-based assessment of 
      cognitive function and behavioral/emotional symptoms to screen for neurocognitive 
      dysfunction in childhood-onset systemic lupus erythematosus (cSLE). METHODS: 
      Forty children with cSLE and 24 healthy controls ages 10-16 years were enrolled. 
      Formal neurocognitive testing (FNCT) was done to determine cognitive performance 
      in 4 key areas that appear to be sensitive to the adverse effects of cSLE: 
      attention, working memory, psychomotor speed, and visuoconstructional ability. 
      Paper and pencil questionnaires sampling cognitive functioning and 
      behavioral/emotional symptoms were also completed: the Subjective Awareness of 
      Neuropsychological Deficits for Children (SAND-C) questionnaire by patients, and 
      the Child Behavioral Checklist and the Behavior Rating Inventory of Executive 
      Function (BRIEF) by parents. RESULTS: Domain and summary scores of the BRIEF and 
      SAND-C correlated modestly with participants' performance on FNCT. Questionnaire 
      ratings did not discriminate subjects with different levels of cognitive ability 
      as measured by FNCT. CONCLUSION: Contrary to some reports in adults with SLE, 
      self-administered questionnaires of cognitive functioning and parent ratings of 
      executive functioning do not appear well suited to replace FNCT in screening for 
      neurocognitive impairment of children and adolescents with cSLE. However, they 
      may provide information that is complementary to FNCT and therefore play a useful 
      role in clinical followup.
FAU - Vega-Fernandez, Patricia
AU  - Vega-Fernandez P
FAU - Zelko, Frank A
AU  - Zelko FA
FAU - Klein-Gitelman, Marisa
AU  - Klein-Gitelman M
FAU - Lee, Jiha
AU  - Lee J
FAU - Hummel, Jessica
AU  - Hummel J
FAU - Nelson, Shannen
AU  - Nelson S
FAU - Thomas, Erin C
AU  - Thomas EC
FAU - Ying, Jun
AU  - Ying J
FAU - Beebe, Dean W
AU  - Beebe DW
FAU - Brunner, Hermine I
AU  - Brunner HI
LA  - eng
GR  - UL1 TR000077/TR/NCATS NIH HHS/United States
GR  - P60-AR47784/AR/NIAMS NIH HHS/United States
GR  - 5UL1RR026314-03/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Arthritis Care Res (Hoboken)
JT  - Arthritis care & research
JID - 101518086
SB  - IM
MH  - Adolescent
MH  - Age Factors
MH  - Child
MH  - Cognition Disorders/diagnosis/epidemiology/*psychology
MH  - Female
MH  - Humans
MH  - Lupus Erythematosus, Systemic/diagnosis/epidemiology/*psychology
MH  - Male
MH  - Neuropsychological Tests/*standards
MH  - *Proxy/psychology
MH  - Self Report/*standards
MH  - Surveys and Questionnaires/*standards
EDAT- 2013/12/18 06:00
MHDA- 2014/07/18 06:00
CRDT- 2013/12/17 06:00
PHST- 2013/07/30 00:00 [received]
PHST- 2013/10/30 00:00 [revised]
PHST- 2013/11/26 00:00 [accepted]
PHST- 2013/12/17 06:00 [entrez]
PHST- 2013/12/18 06:00 [pubmed]
PHST- 2014/07/18 06:00 [medline]
AID - 10.1002/acr.22247 [doi]
PST - ppublish
SO  - Arthritis Care Res (Hoboken). 2014 Jun;66(6):943-8. doi: 10.1002/acr.22247.