PMID- 24339697
OWN - NLM
STAT- MEDLINE
DCOM- 20140826
LR  - 20211021
IS  - 1598-6357 (Electronic)
IS  - 1011-8934 (Print)
IS  - 1011-8934 (Linking)
VI  - 28
IP  - 12
DP  - 2013 Dec
TI  - Comparison of the safety of seven iodinated contrast media.
PG  - 1703-10
LID - 10.3346/jkms.2013.28.12.1703 [doi]
AB  - We aimed to determine the characteristic adverse events (AEs) of iodinated 
      contrast media (IOCM) and to compare the safety profiles of different IOCM. This 
      study used the database of AEs reports submitted by healthcare professionals from 
      15 Regional Pharmacovigilance Centers between June 24, 2009 and December 31, 2010 
      in Korea. All reports of IOCM, including iopromide, iohexol, iopamidol, iomeprol, 
      ioversol, iobitridol and iodixanol, were analyzed. Safety profiles were compared 
      between different IOCM at the system organ level using the proportional reporting 
      ratio (PRR) and 95% confidence interval (95% CI). Among a total of 48,261 
      reports, 6,524 (13.5%) reports were related to the use of IOCM. Iopromide 
      (45.5%), iohexol (16.9%), iopamidol (14.3%) and iomeprol (10.3%) were identified 
      as frequently reported media. 'Platelet, bleeding & clotting disorders' (PRR, 
      29.6; 95%CI, 1.9-472.6) and 'urinary system disorders' (PRR, 22.3; 95% CI, 
      17.1-29.1) were more frequently reported for iodixanol than the other IOCM. In 
      conclusion, the frequency of AEs by organ class was significantly different 
      between individual media. These differences among different IOCM should be 
      considered when selecting a medium among various IOCM and when monitoring 
      patients during and after its use to ensure optimum usage and patient safety.
FAU - Seong, Jong-Mi
AU  - Seong JM
AD  - Office of Drug Safety Information II, Korea Institute of Drug Safety & Risk 
      Management, Seoul, Korea. ; Department of Preventive Medicine, Seoul National 
      University College of Medicine, Seoul, Korea.
FAU - Choi, Nam-Kyong
AU  - Choi NK
FAU - Lee, Joongyub
AU  - Lee J
FAU - Chang, Yoosoo
AU  - Chang Y
FAU - Kim, Ye-Jee
AU  - Kim YJ
FAU - Yang, Bo Ram
AU  - Yang BR
FAU - Jin, Xue-Mei
AU  - Jin XM
FAU - Kim, Ju-Young
AU  - Kim JY
FAU - Park, Byung-Joo
AU  - Park BJ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131126
PL  - Korea (South)
TA  - J Korean Med Sci
JT  - Journal of Korean medical science
JID - 8703518
RN  - 0 (Contrast Media)
RN  - 0 (Iodine Radioisotopes)
RN  - 0 (Radiopharmaceuticals)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Blood Platelet Disorders/chemically induced
MH  - Child
MH  - Child, Preschool
MH  - Contrast Media/*adverse effects
MH  - Databases, Factual
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Iodine Radioisotopes/chemistry
MH  - Male
MH  - Middle Aged
MH  - Neoplasms/diagnostic imaging
MH  - Radionuclide Imaging
MH  - Radiopharmaceuticals/*adverse effects
MH  - Urologic Diseases/chemically induced
MH  - Young Adult
PMC - PMC3857363
OTO - NOTNLM
OT  - Adverse Drug Reaction Reporting Systems
OT  - Contrast Media
OT  - Patient Safety
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2013/12/18 06:00
MHDA- 2014/08/27 06:00
PMCR- 2013/12/01
CRDT- 2013/12/17 06:00
PHST- 2013/07/01 00:00 [received]
PHST- 2013/09/30 00:00 [accepted]
PHST- 2013/12/17 06:00 [entrez]
PHST- 2013/12/18 06:00 [pubmed]
PHST- 2014/08/27 06:00 [medline]
PHST- 2013/12/01 00:00 [pmc-release]
AID - 10.3346/jkms.2013.28.12.1703 [doi]
PST - ppublish
SO  - J Korean Med Sci. 2013 Dec;28(12):1703-10. doi: 10.3346/jkms.2013.28.12.1703. 
      Epub 2013 Nov 26.