PMID- 24341094
OWN - NLM
STAT- MEDLINE
DCOM- 20150423
LR  - 20131216
IS  - 1009-3591 (Print)
IS  - 1009-3591 (Linking)
VI  - 19
IP  - 11
DP  - 2013 Nov
TI  - [Application value of diagnostic TURP for patients with serum PSA abnormality].
PG  - 999-1002
AB  - OBJECTIVE: To assess the application value of diagnostic transurethral resection 
      of the prostate (TURP) for benign prostatic hyperplasia (BPH) patients with 
      persistently abnormal serum PSA levels. METHODS: We performed TURP for 71 BPH 
      patients with the PSA level > 4 microg/L, and analyzed the Gleason scores and 
      prognosis of the cases pathologically confirmed as prostate cancer (PCa). We 
      conducted follow-up visits to all the patients, obtained the PSA levels and 
      International Prostate Symptom scores (IPSS) at 6 and 12 months after TURP, 
      analyzed their changes and assessed the value of TURP in the diagnosis and 
      treatment of BPH with serum PSA abnormality. RESULTS: Among the 40 patients with 
      negative prostate biopsy and persistent serum PSA abnormality, 2 cases were 
      diagnosed as Gleason score 6 prostatic adenocarcinoma by TURP biopsy, and 1 case 
      as Gleason score 6 PCa by repeated biopsy. All the 3 patients underwent radical 
      prostatectomies and were well recovered during the follow-up visits. Of the 31 
      patients who had refused biopsy, 9 cases were confirmed by postoperative 
      pathology as Gleason score 7 -9 PCa, 1 treated by radical prostatectomy and the 
      other 8 by endocrine therapy. Another 59 cases were pathologically diagnosed as 
      BPH, of which, the serum PSA level was restored to normal in 56 and significantly 
      reduced in the other 3, and IPSS was remarkably increased in 53 and improved in 
      the other 6 following urethral soundings. CONCLUSION: Diagnostic TURP can 
      increase the early diagnosis rate of PCa, improve lower urinary tract symptoms 
      (LUTS) and help to normalize the serum PSA level. Therefore, it can be chosen for 
      those with persistent serum PSA abnormality, LUTS and negative prostate biopsy.
FAU - Yuan, Jun
AU  - Yuan J
AD  - Department of Urology, Jiangyin Hospital Affiliated to Southeast University 
      Medical College, Wuxi, Jiangsu 214400, China.
FAU - Zhao, Hu
AU  - Zhao H
AD  - Department of Urology, Jiangyin Hospital Affiliated to Southeast University 
      Medical College, Wuxi, Jiangsu 214400, China.
FAU - Wu, Bin
AU  - Wu B
AD  - Department of Urology, Jiangyin Hospital Affiliated to Southeast University 
      Medical College, Wuxi, Jiangsu 214400, China.
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Nan Ke Xue
JT  - Zhonghua nan ke xue = National journal of andrology
JID - 101093592
RN  - EC 3.4.21.77 (Prostate-Specific Antigen)
SB  - IM
MH  - Adenocarcinoma/*diagnosis
MH  - Biopsy
MH  - Humans
MH  - Lower Urinary Tract Symptoms/diagnosis
MH  - Male
MH  - Prognosis
MH  - Prostate/pathology
MH  - Prostate-Specific Antigen/*blood
MH  - Prostatic Hyperplasia/*diagnosis
MH  - Prostatic Neoplasms/*diagnosis
MH  - *Transurethral Resection of Prostate
EDAT- 2013/12/18 06:00
MHDA- 2015/04/24 06:00
CRDT- 2013/12/18 06:00
PHST- 2013/12/18 06:00 [entrez]
PHST- 2013/12/18 06:00 [pubmed]
PHST- 2015/04/24 06:00 [medline]
PST - ppublish
SO  - Zhonghua Nan Ke Xue. 2013 Nov;19(11):999-1002.