PMID- 24341410
OWN - NLM
STAT- MEDLINE
DCOM- 20150911
LR  - 20211021
IS  - 1365-2125 (Electronic)
IS  - 0306-5251 (Print)
IS  - 0306-5251 (Linking)
VI  - 79
IP  - 2
DP  - 2015 Feb
TI  - The prevention and management of infections due to multidrug resistant organisms 
      in haematology patients.
PG  - 195-207
LID - 10.1111/bcp.12310 [doi]
AB  - Infections due to resistant and multidrug resistant (MDR) organisms in 
      haematology patients and haematopoietic stem cell transplant recipients are an 
      increasingly complex problem of global concern. We outline the burden of illness 
      and epidemiology of resistant organisms such as gram-negative pathogens, 
      vancomycin-resistant Enterococcus faecium (VRE), and Clostridium difficile in 
      haematology cohorts. Intervention strategies aimed at reducing the impact of 
      these organisms are reviewed: infection prevention programmes, screening and 
      fluoroquinolone prophylaxis. The role of newer therapies (e.g. linezolid, 
      daptomycin and tigecycline) for treatment of resistant and MDR organisms in 
      haematology populations is evaluated, in addition to the mobilization of older 
      agents (e.g. colistin, pristinamycin and fosfomycin) and the potential benefit of 
      combination regimens.
CI  - (c) 2013 The British Pharmacological Society.
FAU - Trubiano, Jason A
AU  - Trubiano JA
AD  - Department of Infectious Diseases, Peter MacCallum Cancer Centre, East Melbourne, 
      VIC.
FAU - Worth, Leon J
AU  - Worth LJ
FAU - Thursky, Karin A
AU  - Thursky KA
FAU - Slavin, Monica A
AU  - Slavin MA
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Br J Clin Pharmacol
JT  - British journal of clinical pharmacology
JID - 7503323
RN  - 0 (Anti-Bacterial Agents)
SB  - IM
MH  - Anti-Bacterial Agents/administration & dosage/*pharmacology
MH  - Antibiotic Prophylaxis/methods
MH  - Bacterial Infections/*drug therapy/microbiology/prevention & control
MH  - Cost of Illness
MH  - Drug Resistance, Multiple, Bacterial
MH  - Global Health
MH  - Hematologic Diseases/*complications
MH  - Hematopoietic Stem Cell Transplantation/methods
MH  - Humans
PMC - PMC4309626
OTO - NOTNLM
OT  - fluoroquinolone prophylaxis
OT  - haematology
OT  - healthcare-associated infection
OT  - multiresistant gram negatives
OT  - vancomycin-resistant enterococci (VRE)
EDAT- 2013/12/18 06:00
MHDA- 2015/09/12 06:00
PMCR- 2016/02/01
CRDT- 2013/12/18 06:00
PHST- 2013/10/28 00:00 [received]
PHST- 2013/12/09 00:00 [accepted]
PHST- 2013/12/18 06:00 [entrez]
PHST- 2013/12/18 06:00 [pubmed]
PHST- 2015/09/12 06:00 [medline]
PHST- 2016/02/01 00:00 [pmc-release]
AID - 10.1111/bcp.12310 [doi]
PST - ppublish
SO  - Br J Clin Pharmacol. 2015 Feb;79(2):195-207. doi: 10.1111/bcp.12310.