PMID- 24341549
OWN - NLM
STAT- MEDLINE
DCOM- 20141006
LR  - 20140210
IS  - 1600-0897 (Electronic)
IS  - 1046-7408 (Linking)
VI  - 71
IP  - 3
DP  - 2014 Mar
TI  - Maternal circulating dendritic cell subtypes at delivery and during the 1-year 
      postpartum period.
PG  - 210-6
LID - 10.1111/aji.12188 [doi]
AB  - PROBLEM: Dendritic cells (DCs) play an important role in maintaining pregnancy by 
      inducing tolerance toward the fetus. Such an immunologic change in the mother 
      should be restored to normal after delivery, but few studies have reported 
      postpartum maternal immune recovery, in terms of the types circulating DCs. 
      METHOD OF STUDY: The level of each DC subtype and HLA-DR-positive 
      immunoreactivity of the blood from 29 pregnant women with uncomplicated labor was 
      serially analyzed by flowcytometry at delivery and at 1.5, 6, and 12 months after 
      delivery. DC subtypes were characterized as myeloid, lymphoid, and less 
      differentiated (ldDC). Mean fluorescence intensity (MFI) was evaluated for HLA-DR 
      expression for each DC subtype. RESULTS: The total number and the percentage of 
      DCs at delivery were lower than those at 12 months postpartum. The ldDC fractions 
      were significantly higher at delivery and at 1.5 months than at 12 months 
      postpartum. The MFI of HLA-DR expression on ldDCs at delivery was lower than that 
      at 12 months postpartum. The myeloid-to-lymphoid DC ratio did not differ over the 
      1-year postpartum period. CONCLUSION: The maternal alteration in DCs rapidly 
      normalized within 1.5 months, except for the ldDC fraction, which persisted 
      between 1.5 and 6 months after delivery.
CI  - (c) 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Lee, Hye Ryun
AU  - Lee HR
AD  - Department of Laboratory Medicine, Gyeongsang National University Hospital, 
      Jinju, Korea.
FAU - Kim, Byoung Jae
AU  - Kim BJ
FAU - Shin, Sue
AU  - Shin S
FAU - Jeon, Hye Won
AU  - Jeon HW
FAU - Roh, Eun Youn
AU  - Roh EY
FAU - Yoon, Jong Hyun
AU  - Yoon JH
FAU - Song, Eun Young
AU  - Song EY
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20131216
PL  - Denmark
TA  - Am J Reprod Immunol
JT  - American journal of reproductive immunology (New York, N.Y. : 1989)
JID - 8912860
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Adult
MH  - Blood Circulation/immunology
MH  - Cell Differentiation/immunology
MH  - Cell Separation
MH  - *Delivery, Obstetric
MH  - Dendritic Cells/*immunology
MH  - Female
MH  - Flow Cytometry
MH  - HLA-DR Antigens/metabolism
MH  - Humans
MH  - Postpartum Period/*immunology
MH  - Pregnancy
MH  - Time Factors
MH  - Transplantation Tolerance
MH  - Young Adult
OTO - NOTNLM
OT  - Dendritic cells
OT  - mean fluorescence intensity
OT  - postpartum
EDAT- 2013/12/18 06:00
MHDA- 2014/10/07 06:00
CRDT- 2013/12/18 06:00
PHST- 2013/09/07 00:00 [received]
PHST- 2013/11/18 00:00 [accepted]
PHST- 2013/12/18 06:00 [entrez]
PHST- 2013/12/18 06:00 [pubmed]
PHST- 2014/10/07 06:00 [medline]
AID - 10.1111/aji.12188 [doi]
PST - ppublish
SO  - Am J Reprod Immunol. 2014 Mar;71(3):210-6. doi: 10.1111/aji.12188. Epub 2013 Dec 
      16.