PMID- 24341880
OWN - NLM
STAT- MEDLINE
DCOM- 20140829
LR  - 20151119
IS  - 1750-7448 (Electronic)
IS  - 1750-743X (Linking)
VI  - 6
IP  - 1
DP  - 2014
TI  - Partial recovery after severe immune reconstitution inflammatory syndrome in a 
      multiple sclerosis patient with progressive multifocal leukoencephalopathy.
PG  - 23-8
LID - 10.2217/imt.13.155 [doi]
AB  - Progressive multifocal leukoencephalopathy (PML) is a rare and severe 
      complication of natalizumab therapy in patients with multiple sclerosis and it 
      may be accompanied by immune reconstitution inflammatory syndrome (IRIS). Here, 
      we describe a case of abnormally severe IRIS, which occurred 2 months after 
      natalizumab-associated PML in a 38-year-old woman affected by multiple sclerosis. 
      The patient was John Cunningham virus-positive and was treated for 21 months when 
      she developed PML. The subsequent IRIS diffusely afflicted the brain, producing 
      edema and signs of intracranial hypertension, with a clinically severe form 
      compromising the state of consciousness, requiring intensive care and high-dosage 
      steroid treatment. Nevertheless, she survived and partially recovered. There is 
      still difficulty in differentiating PML progression from IRIS onset and there is 
      not a clear description in the literature about different clinical forms of IRIS, 
      prognostic factors and guidelines to properly treat this complication in order to 
      reduce the residual disability of the patient surviving this treatment 
      complication.
FAU - Calvi, Alberto
AU  - Calvi A
AD  - Neurology Unit, Department of Pathophysiology & Transplantation, 'Dino Ferrari' 
      Center, University of Milan, Fondazione Ca Granda, IRCCS Ospedale Maggiore 
      Policlinico, Milan, Italy.
FAU - De Riz, Milena
AU  - De Riz M
FAU - Pietroboni, Anna M
AU  - Pietroboni AM
FAU - Ghezzi, Laura
AU  - Ghezzi L
FAU - Maltese, Virginia
AU  - Maltese V
FAU - Arighi, Andrea
AU  - Arighi A
FAU - Fumagalli, Giorgio G
AU  - Fumagalli GG
FAU - Jacini, Francesca
AU  - Jacini F
FAU - Donelli, Carlotta
AU  - Donelli C
FAU - Comi, Giancarlo
AU  - Comi G
FAU - Galimberti, Daniela
AU  - Galimberti D
FAU - Scarpini, Elio
AU  - Scarpini E
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Immunotherapy
JT  - Immunotherapy
JID - 101485158
RN  - 0 (Antibodies, Monoclonal, Humanized)
RN  - 0 (Immunosuppressive Agents)
RN  - 0 (Natalizumab)
RN  - 0 (Steroids)
SB  - IM
MH  - Adult
MH  - Antibodies, Monoclonal, Humanized/administration & dosage/adverse effects
MH  - Brain/*drug effects/pathology/virology
MH  - Disease-Free Survival
MH  - Female
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/*drug therapy/etiology
MH  - Immunosuppressive Agents/administration & dosage/adverse effects
MH  - JC Virus/*physiology
MH  - Language Disorders
MH  - Leukoencephalopathy, Progressive Multifocal/*drug therapy/etiology
MH  - Multiple Sclerosis/complications/*drug therapy
MH  - Natalizumab
MH  - Plasma Exchange
MH  - Recovery of Function
MH  - Steroids/administration & dosage
MH  - Viral Load/drug effects
EDAT- 2013/12/18 06:00
MHDA- 2014/08/30 06:00
CRDT- 2013/12/18 06:00
PHST- 2013/12/18 06:00 [entrez]
PHST- 2013/12/18 06:00 [pubmed]
PHST- 2014/08/30 06:00 [medline]
AID - 10.2217/imt.13.155 [doi]
PST - ppublish
SO  - Immunotherapy. 2014;6(1):23-8. doi: 10.2217/imt.13.155.