PMID- 24342553
OWN - NLM
STAT- MEDLINE
DCOM- 20141027
LR  - 20140303
IS  - 1873-0329 (Electronic)
IS  - 1383-5769 (Linking)
VI  - 63
IP  - 2
DP  - 2014 Apr
TI  - Impaired protection against Trichinella spiralis in mice with high levels of IgE.
PG  - 332-6
LID - S1383-5769(13)00205-5 [pii]
LID - 10.1016/j.parint.2013.12.004 [doi]
AB  - Helminth infection induces production of a large amount of immunoglobulin E (IgE) 
      to nonhelminth antigens. Although such "irrelevant" IgE is a major proportion of 
      total IgE in the host, its biological significance remains unclear. Therefore, I 
      examined protective activity against Trichinella spiralis in mice with high 
      levels of IgE by repeated injections of anti-dansyl IgE monoclonal antibody or 
      Nippostrongylus brasiliensis infection. Injected anti-dansyl IgE occupied IgE 
      receptors on mast cells in naive mice. Protective activity against T. spiralis, 
      determined with number of muscle larvae 5weeks after infection, was impaired in 
      mice treated with anti-dansyl IgE. The impaired protection was found in mice 
      treated with anti-dansy IgE 7 and 14days after infection, but not 21 and 28days 
      after infection, indicating that IgE-dependent protection operates at an early 
      stage after infection. In the next experiments, mice were infected with N. 
      brasiliensis 4weeks before T. spiralis infection to obtain high levels of IgE. 
      The protective activity against T. spiralis was decreased by N. brasiliensis 
      infection. On the other hand, protection against T. spiralis was comparable in 
      IgE-deficient SJA/9 mice and in anti-IgE-treated BALB/c mice with or without N. 
      brasiliensis infection, suggesting that impairment of protection is dependent on 
      IgE. These results indicate that the high levels of irrelevant IgE are beneficial 
      for helminths and, alternatively, that anti-helminth IgE antibodies are 
      protective for hosts. In addition, the impaired protection was found in IgE 
      high-responder mice but not in low-responder mice, suggesting that protection 
      against T. spiralis is controlled by IgE responsiveness in the host.
CI  - Copyright (c) 2013 Elsevier B.V. All rights reserved.
FAU - Watanabe, Naohiro
AU  - Watanabe N
AD  - Department of Allergology, The Jikei University School of Medicine, Japan; 
      Department of Allergology, The Jikei University School of Medicine, 3-25-8 
      Nishishinbashi, Minato-ku, Tokyo 105-8461, Japan. Electronic address: 
      naohiro@jikei.ac.jp.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131215
PL  - Netherlands
TA  - Parasitol Int
JT  - Parasitology international
JID - 9708549
RN  - 0 (Antibodies, Monoclonal)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - Antibodies, Monoclonal
MH  - Immunoglobulin E/*immunology
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Nippostrongylus/immunology
MH  - Rats
MH  - Rats, Wistar
MH  - Trichinella spiralis/*immunology
MH  - Trichinellosis/immunology/*parasitology
OTO - NOTNLM
OT  - Immunoglobulin E
OT  - Mouse
OT  - Nippostrongylus brasiliensis
OT  - Protection
OT  - Trichinella spiralis
EDAT- 2013/12/18 06:00
MHDA- 2014/10/28 06:00
CRDT- 2013/12/18 06:00
PHST- 2013/09/09 00:00 [received]
PHST- 2013/11/25 00:00 [revised]
PHST- 2013/12/09 00:00 [accepted]
PHST- 2013/12/18 06:00 [entrez]
PHST- 2013/12/18 06:00 [pubmed]
PHST- 2014/10/28 06:00 [medline]
AID - S1383-5769(13)00205-5 [pii]
AID - 10.1016/j.parint.2013.12.004 [doi]
PST - ppublish
SO  - Parasitol Int. 2014 Apr;63(2):332-6. doi: 10.1016/j.parint.2013.12.004. Epub 2013 
      Dec 15.