PMID- 24343089
OWN - NLM
STAT- MEDLINE
DCOM- 20140802
LR  - 20171116
IS  - 1671-167X (Print)
IS  - 1671-167X (Linking)
VI  - 45
IP  - 6
DP  - 2013 Dec 18
TI  - [8p11 myeloproliferative syndrome cured by allogeneic hematopoietic stem cell 
      transplantation: two case reports and literature review].
PG  - 993-6
AB  - OBJECTIVE: To report 2 rare cases of 8p11 meyloproliferative syndrome cured by 
      allogeneic hematopoietic stem cell transplantation. METHODS: The clinical and 
      laboratory features of 2 cases of 8p11 meyloproliferative syndrome were 
      summarized, including the diagnosis and treatment process of allogeneic 
      hematopoietic stem cell transplantation. RESULTS: Patient 1 was presented with 
      bilateral cervical lymphadenopathy and leukocytosis. The pathology of bone marrow 
      showed extremely hyperplasia. The cytogenetic analysis showed a 46, XY, 
      (8;13)(p11;q12) karyotype. The biopsy of the lymph node was peripheral T-cell 
      lymphoma, unspecified. Patient 2 was presented with extensive lymphadenopathy 
      with abnormal hemogram, which was leuekcytosis and thrombpenia. The bone marrow 
      was hypercellular. The cytogenetic analysis on the bone marrow cells showed a 
      translocation of t(8;9) (p11;q32). The CEP110-FGFR1 fusion transcript was 
      detected by RT-PCR. The biopsy of the lymph node was T lymphoblastic lymphoma. 
      These two patients received human leukocyte antigen (HLA)-identical allogeneic 
      hematopoietic stem cell transplantation, remained disease-free and survived 16 
      years and 6 years after transplantation, respectively. CONCLUSION: Allogeneic 
      hematopoietic stem cell transplantation is the curative therapy for 8p11 
      meyloproliferative syndrome.
FAU - Xu, Lan-ping
AU  - Xu LP
AD  - Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell 
      Transplantation, Peking University People's Hospital, Beijing 100044, China.
FAU - Chen, Yao
AU  - Chen Y
FAU - Shi, Hong-xia
AU  - Shi HX
FAU - Huang, Xiao-jun
AU  - Huang XJ
LA  - chi
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - China
TA  - Beijing Da Xue Xue Bao Yi Xue Ban
JT  - Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health 
      sciences
JID - 101125284
SB  - IM
MH  - Adult
MH  - Chromosomes, Human, Pair 8/genetics
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Humans
MH  - Male
MH  - Myeloproliferative Disorders/diagnosis/genetics/*therapy
MH  - Translocation, Genetic
MH  - Transplantation, Homologous
EDAT- 2013/12/18 06:00
MHDA- 2014/08/03 06:00
CRDT- 2013/12/18 06:00
PHST- 2013/12/18 06:00 [entrez]
PHST- 2013/12/18 06:00 [pubmed]
PHST- 2014/08/03 06:00 [medline]
PST - ppublish
SO  - Beijing Da Xue Xue Bao Yi Xue Ban. 2013 Dec 18;45(6):993-6.