PMID- 2434340
OWN - NLM
STAT- MEDLINE
DCOM- 19870409
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 131
IP  - 1
DP  - 1986 Nov 12
TI  - The central pressor actions of substance P are inhibited by GABA.
PG  - 31-7
AB  - The influence of GABA-ergic stimulation on the centrally evoked pressor and 
      tachycardic responses to substance P (SP) was investigated in conscious rats. 
      Intracerebroventricular (i.c.v.) pretreatment with the potent GABA agonist 
      muscimol attenuated the pressor responses to i.c.v. administered SP in a 
      dose-dependent and reversible fashion. Inhibition was maximal 5-60 min after 
      muscimol injection and lasted up to 3 h. In contrast, the increases in heart rate 
      in response to i.c.v. administered SP were not consistently inhibited by 
      muscimol. Central pretreatment with muscimol prevented the increase of plasma 
      adrenaline but not of plasma noradrenaline in response to i.c.v. administered SP. 
      Our results demonstrate that the GABA-ergic system can exert an inhibitory 
      control on pathways mediating the central pressor actions of SP. The selective 
      inhibition of adrenaline secretion by muscimol implies that suppression of 
      sympathetic outflow to the adrenal gland may be involved as an important 
      mechanism. In addition, our findings point to a dissociation between pathways 
      mediating the pressor and tachycardic effects of SP.
FAU - Schneider, B
AU  - Schneider B
FAU - Ganten, D
AU  - Ganten D
FAU - Lang, R E
AU  - Lang RE
FAU - Unger, T
AU  - Unger T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Catecholamines)
RN  - 2763-96-4 (Muscimol)
RN  - 33507-63-0 (Substance P)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
SB  - IM
MH  - Animals
MH  - Blood Pressure/*drug effects
MH  - Catecholamines/blood
MH  - Heart Rate/drug effects
MH  - Injections, Intravenous
MH  - Male
MH  - Muscimol/pharmacology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Substance P/*antagonists & inhibitors
MH  - gamma-Aminobutyric Acid/*pharmacology
EDAT- 1986/11/12 00:00
MHDA- 1986/11/12 00:01
CRDT- 1986/11/12 00:00
PHST- 1986/11/12 00:00 [pubmed]
PHST- 1986/11/12 00:01 [medline]
PHST- 1986/11/12 00:00 [entrez]
AID - 0014-2999(86)90512-1 [pii]
AID - 10.1016/0014-2999(86)90512-1 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 1986 Nov 12;131(1):31-7. doi: 10.1016/0014-2999(86)90512-1.