PMID- 24343415
OWN - NLM
STAT- MEDLINE
DCOM- 20150112
LR  - 20151119
IS  - 1559-0259 (Electronic)
IS  - 1530-7905 (Linking)
VI  - 14
IP  - 2
DP  - 2014 Jun
TI  - Effects of histidine and N-acetylcysteine on doxorubicin-induced cardiomyopathy 
      in rats.
PG  - 153-61
LID - 10.1007/s12012-013-9239-6 [doi]
AB  - The amino acids histidine and n-acetylcysteine have many biological activities 
      such as antioxidant effect. The present study investigated the effects of 
      histidine and n-acetylcysteine on the heart lesions induced by doxorubicin (DOX) 
      in rats. Forty-eight male Wistar rats were divided into two major groups treated 
      intraperitoneally (i.p.) with normal saline and 4 mg/kg of DOX, respectively. 
      Each group was further divided into four subgroups that were treated with 
      separate and combined i.p. injections of histidine and n-acetylcysteine (NAC) at 
      a same dose of 40 mg/kg. Electrocardiography (ECG) was recorded using lead II. 
      The heart lesions were evaluated by light microscopy. Serum levels of creatine 
      phosphokinase and lactate dehydrogenase and heart tissue malondialdehyde levels 
      were measured. Histidine and especially NAC at a same dose of 40 mg/kg recovered 
      ECG changes, improved heart lesions and prevented biochemical changes induced by 
      DOX. Co-administration of histidine and NAC showed better responses when compared 
      with them used alone. The results of the present study showed protective effects 
      for histidine and NAC on the heart. Reduction in free radical-induced toxic 
      effects may be involved in cardioprotective properties of histidine and NAC.
FAU - Farshid, Amir Abbas
AU  - Farshid AA
AD  - Department of Pathobiology, Faculty of Veterinary Medicine, Urmia University, 
      57153-1177, Urmia, Iran, amirabbasfarshidkh@gmail.com.
FAU - Tamaddonfard, Esmaeal
AU  - Tamaddonfard E
FAU - Simaee, Naeime
AU  - Simaee N
FAU - Mansouri, Sanam
AU  - Mansouri S
FAU - Najafi, Sima
AU  - Najafi S
FAU - Asri-Rezaee, Siamak
AU  - Asri-Rezaee S
FAU - Alavi, Hossein
AU  - Alavi H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cardiovasc Toxicol
JT  - Cardiovascular toxicology
JID - 101135818
RN  - 0 (Biomarkers)
RN  - 0 (Free Radical Scavengers)
RN  - 4QD397987E (Histidine)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - 80168379AG (Doxorubicin)
RN  - EC 1.1.1.27 (L-Lactate Dehydrogenase)
RN  - EC 2.7.3.2 (Creatine Kinase)
RN  - WYQ7N0BPYC (Acetylcysteine)
SB  - IM
MH  - Acetylcysteine/*pharmacology
MH  - Animals
MH  - Biomarkers/blood
MH  - Cardiomyopathies/chemically 
      induced/metabolism/pathology/physiopathology/*prevention & control
MH  - Creatine Kinase/blood
MH  - Cytoprotection
MH  - Disease Models, Animal
MH  - Dose-Response Relationship, Drug
MH  - *Doxorubicin
MH  - Drug Therapy, Combination
MH  - Electrocardiography
MH  - Free Radical Scavengers/*pharmacology
MH  - Heart Rate/drug effects
MH  - Histidine/*pharmacology
MH  - L-Lactate Dehydrogenase/blood
MH  - Male
MH  - Malondialdehyde/metabolism
MH  - Myocardium/metabolism/pathology
MH  - Rats, Wistar
MH  - Recovery of Function
EDAT- 2013/12/18 06:00
MHDA- 2015/01/13 06:00
CRDT- 2013/12/18 06:00
PHST- 2013/12/18 06:00 [entrez]
PHST- 2013/12/18 06:00 [pubmed]
PHST- 2015/01/13 06:00 [medline]
AID - 10.1007/s12012-013-9239-6 [doi]
PST - ppublish
SO  - Cardiovasc Toxicol. 2014 Jun;14(2):153-61. doi: 10.1007/s12012-013-9239-6.