PMID- 24345321
OWN - NLM
STAT- MEDLINE
DCOM- 20140424
LR  - 20140217
IS  - 1879-1891 (Electronic)
IS  - 0002-9394 (Linking)
VI  - 157
IP  - 3
DP  - 2014 Mar
TI  - Effect of scan quality on diagnostic accuracy of spectral-domain optical 
      coherence tomography in glaucoma.
PG  - 719-27.e1
LID - S0002-9394(13)00782-4 [pii]
LID - 10.1016/j.ajo.2013.12.012 [doi]
AB  - PURPOSE: To evaluate the effect of scan quality on the diagnostic accuracies of 
      optic nerve head (ONH), retinal nerve fiber layer (RNFL), and ganglion cell 
      complex (GCC) parameters of spectral-domain optical coherence tomography (SD OCT) 
      in glaucoma. DESIGN: Cross-sectional study. METHODS: Two hundred fifty-two eyes 
      of 183 control subjects (mean deviation [MD]: -1.84 dB) and 207 eyes of 159 
      glaucoma patients (MD: -7.31 dB) underwent ONH, RNFL, and GCC scanning with SD 
      OCT. Scan quality of SD OCT images was based on signal strength index (SSI) 
      values. Influence of SSI on diagnostic accuracy of SD OCT was evaluated by 
      receiver operating characteristic (ROC) regression. RESULTS: Diagnostic 
      accuracies of all SD OCT parameters were better when the SSI values were higher. 
      This effect was statistically significant (P < .05) for ONH and RNFL but not for 
      GCC parameters. In mild glaucoma (MD of -5 dB), area under ROC curve (AUC) for 
      rim area, average RNFL thickness, and average GCC thickness parameters improved 
      from 0.651, 0.678, and 0.726, respectively, at an SSI value of 30 to 0.873, 
      0.962, and 0.886, respectively, at an SSI of 70. AUCs of the same parameters in 
      advanced glaucoma (MD of -15 dB) improved from 0.747, 0.890, and 0.873, 
      respectively, at an SSI value of 30 to 0.922, 0.994, and 0.959, respectively, at 
      an SSI of 70. CONCLUSION: Diagnostic accuracies of SD OCT parameters in glaucoma 
      were significantly influenced by the scan quality even when the SSI values were 
      within the manufacturer-recommended limits. These results should be considered 
      while interpreting the SD OCT scans for glaucoma.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Rao, Harsha L
AU  - Rao HL
AD  - Vazir Sultan Tobacco (VST) Glaucoma Center, L. V. Prasad Eye Institute, Banjara 
      Hills, Hyderabad, India; Center for Clinical Epidemiology and Biostatistics, L. 
      V. Prasad Eye Institute, Banjara Hills, Hyderabad, India. Electronic address: 
      harshalaxmanarao@gmail.com.
FAU - Addepalli, Uday K
AU  - Addepalli UK
AD  - Vazir Sultan Tobacco (VST) Glaucoma Center, L. V. Prasad Eye Institute, Banjara 
      Hills, Hyderabad, India.
FAU - Yadav, Ravi K
AU  - Yadav RK
AD  - Vazir Sultan Tobacco (VST) Glaucoma Center, L. V. Prasad Eye Institute, Banjara 
      Hills, Hyderabad, India.
FAU - Senthil, Sirisha
AU  - Senthil S
AD  - Vazir Sultan Tobacco (VST) Glaucoma Center, L. V. Prasad Eye Institute, Banjara 
      Hills, Hyderabad, India.
FAU - Choudhari, Nikhil S
AU  - Choudhari NS
AD  - Vazir Sultan Tobacco (VST) Glaucoma Center, L. V. Prasad Eye Institute, Banjara 
      Hills, Hyderabad, India.
FAU - Garudadri, Chandra S
AU  - Garudadri CS
AD  - Vazir Sultan Tobacco (VST) Glaucoma Center, L. V. Prasad Eye Institute, Banjara 
      Hills, Hyderabad, India.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131215
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
SB  - IM
MH  - Cross-Sectional Studies
MH  - Diagnostic Techniques, Ophthalmological/*standards
MH  - Glaucoma/*diagnosis
MH  - Humans
MH  - Intraocular Pressure
MH  - Middle Aged
MH  - Nerve Fibers/*pathology
MH  - Optic Disk/*pathology
MH  - Optic Nerve Diseases/*diagnosis
MH  - ROC Curve
MH  - Reproducibility of Results
MH  - Retinal Ganglion Cells/*pathology
MH  - Tomography, Optical Coherence/methods/*standards
MH  - Tonometry, Ocular
EDAT- 2013/12/19 06:00
MHDA- 2014/04/25 06:00
CRDT- 2013/12/19 06:00
PHST- 2013/06/19 00:00 [received]
PHST- 2013/12/06 00:00 [revised]
PHST- 2013/12/06 00:00 [accepted]
PHST- 2013/12/19 06:00 [entrez]
PHST- 2013/12/19 06:00 [pubmed]
PHST- 2014/04/25 06:00 [medline]
AID - S0002-9394(13)00782-4 [pii]
AID - 10.1016/j.ajo.2013.12.012 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2014 Mar;157(3):719-27.e1. doi: 10.1016/j.ajo.2013.12.012. Epub 
      2013 Dec 15.