PMID- 24345398
OWN - NLM
STAT- MEDLINE
DCOM- 20150212
LR  - 20220321
IS  - 1469-5111 (Electronic)
IS  - 1461-1457 (Linking)
VI  - 17
IP  - 4
DP  - 2014 Apr
TI  - The effect of acutely administered MDMA on subjective and BOLD-fMRI responses to 
      favourite and worst autobiographical memories.
PG  - 527-40
LID - 10.1017/S1461145713001405 [doi]
AB  - 3,4-methylenedioxymethamphetamine (MDMA) is a potent monoamine-releaser that is 
      widely used as a recreational drug. Preliminary work has supported the potential 
      of MDMA in psychotherapy for post-traumatic stress disorder (PTSD). The 
      neurobiological mechanisms underlying its putative efficacy are, however, poorly 
      understood. Psychotherapy for PTSD usually requires that patients revisit 
      traumatic memories, and it has been argued that this is easier to do under MDMA. 
      Functional magnetic resonance imaging (fMRI) was used to investigate the effect 
      of MDMA on recollection of favourite and worst autobiographical memories (AMs). 
      Nineteen participants (five females) with previous experience with MDMA performed 
      a blocked AM recollection (AMR) paradigm after ingestion of 100 mg of MDMA-HCl or 
      ascorbic acid (placebo) in a double-blind, repeated-measures design. Memory cues 
      describing participants' AMs were read by them in the scanner. Favourite memories 
      were rated as significantly more vivid, emotionally intense and positive after 
      MDMA than placebo and worst memories were rated as less negative. Functional MRI 
      data from 17 participants showed robust activations to AMs in regions known to be 
      involved in AMR. There was also a significant effect of memory valence: 
      hippocampal regions showed preferential activations to favourite memories and 
      executive regions to worst memories. MDMA augmented activations to favourite 
      memories in the bilateral fusiform gyrus and somatosensory cortex and attenuated 
      activations to worst memories in the left anterior temporal cortex. These 
      findings are consistent with a positive emotional-bias likely mediated by MDMA's 
      pro-monoaminergic pharmacology.
FAU - Carhart-Harris, R L
AU  - Carhart-Harris RL
AD  - Division of Brain Sciences, Faculty of Medicine, Imperial College London, Centre 
      for Neuropsychopharmacology, London, UK.
FAU - Wall, M B
AU  - Wall MB
AD  - Institute of Neurology, University College London, London, UK.
FAU - Erritzoe, D
AU  - Erritzoe D
AD  - Division of Brain Sciences, Faculty of Medicine, Imperial College London, Centre 
      for Neuropsychopharmacology, London, UK.
FAU - Kaelen, M
AU  - Kaelen M
AD  - Division of Brain Sciences, Faculty of Medicine, Imperial College London, Centre 
      for Neuropsychopharmacology, London, UK.
FAU - Ferguson, B
AU  - Ferguson B
AD  - Clinical Psychopharmacology Unit, University College London, London, UK.
FAU - De Meer, I
AU  - De Meer I
AD  - IMANOVA, Centre for Imaging Sciences, London, UK.
FAU - Tanner, M
AU  - Tanner M
AD  - IMANOVA, Centre for Imaging Sciences, London, UK.
FAU - Bloomfield, M
AU  - Bloomfield M
AD  - Division of Brain Sciences, Faculty of Medicine, Imperial College London, Centre 
      for Neuropsychopharmacology, London, UK.
FAU - Williams, T M
AU  - Williams TM
AD  - Division of Brain Sciences, Faculty of Medicine, Imperial College London, Centre 
      for Neuropsychopharmacology, London, UK.
FAU - Bolstridge, M
AU  - Bolstridge M
AD  - Division of Brain Sciences, Faculty of Medicine, Imperial College London, Centre 
      for Neuropsychopharmacology, London, UK.
FAU - Stewart, L
AU  - Stewart L
AD  - Clinical Psychopharmacology Unit, University College London, London, UK.
FAU - Morgan, C J
AU  - Morgan CJ
AD  - Clinical Psychopharmacology Unit, University College London, London, UK.
FAU - Newbould, R D
AU  - Newbould RD
AD  - IMANOVA, Centre for Imaging Sciences, London, UK.
FAU - Feilding, A
AU  - Feilding A
AD  - The Beckley Foundation, Beckley Park, Oxford, UK.
FAU - Curran, H V
AU  - Curran HV
AD  - Clinical Psychopharmacology Unit, University College London, London, UK.
FAU - Nutt, D J
AU  - Nutt DJ
AD  - Division of Brain Sciences, Faculty of Medicine, Imperial College London, Centre 
      for Neuropsychopharmacology, London, UK.
LA  - eng
GR  - MR/J00460X/1/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20131217
PL  - England
TA  - Int J Neuropsychopharmacol
JT  - The international journal of neuropsychopharmacology
JID - 9815893
RN  - 0 (Placebos)
RN  - 0 (Serotonin Agents)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Adult
MH  - Cerebral Cortex/*drug effects
MH  - Double-Blind Method
MH  - Emotions/drug effects
MH  - Female
MH  - Functional Neuroimaging/instrumentation/*methods
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - *Memory, Episodic
MH  - Mental Recall/*drug effects
MH  - N-Methyl-3,4-methylenedioxyamphetamine/administration & dosage/*pharmacology
MH  - Placebos
MH  - Serotonin Agents/administration & dosage/*pharmacology
EDAT- 2013/12/19 06:00
MHDA- 2015/02/13 06:00
CRDT- 2013/12/19 06:00
PHST- 2013/12/19 06:00 [entrez]
PHST- 2013/12/19 06:00 [pubmed]
PHST- 2015/02/13 06:00 [medline]
AID - S1461145713001405 [pii]
AID - 10.1017/S1461145713001405 [doi]
PST - ppublish
SO  - Int J Neuropsychopharmacol. 2014 Apr;17(4):527-40. doi: 
      10.1017/S1461145713001405. Epub 2013 Dec 17.