PMID- 24345766
OWN - NLM
STAT- MEDLINE
DCOM- 20140423
LR  - 20220410
IS  - 0006-3002 (Print)
IS  - 0006-3002 (Linking)
VI  - 1842
IP  - 4
DP  - 2014 Apr
TI  - Coupling energy homeostasis with a mechanism to support plasticity in brain 
      trauma.
PG  - 535-46
LID - S0925-4439(13)00359-1 [pii]
LID - 10.1016/j.bbadis.2013.12.004 [doi]
AB  - Metabolic dysfunction occurring after traumatic brain injury (TBI) is an 
      important risk factor for the development of psychiatric illness. In the present 
      study, we utilized an omega-3 diet during early life as a metabolic 
      preconditioning to alter the course of TBI during adulthood. TBI animals under 
      omega-3 deficiency were more prone to alterations in energy homeostasis 
      (adenosine monophosphate-activated protein kinase; AMPK phosphorylation and 
      cytochrome C oxidase II; COII levels) and mitochondrial biogenesis (peroxisome 
      proliferator-activated receptor gamma coactivator 1-alpha; PGC-1alpha and 
      mitochondrial transcription factor A; TFAM). A similar response was found for 
      brain-derived neurotrophic factor (BDNF) and its signaling through tropomyosin 
      receptor kinase B (TrkB). The results from in vitro studies showed that 
      7,8-dihydroxyflavone (7,8-DHF), a TrkB receptor agonist, upregulates the levels 
      of biogenesis activator PGC-1alpha, and CREB phosphorylation in neuroblastoma cells 
      suggesting that BDNF-TrkB signaling is pivotal for engaging signals related to 
      synaptic plasticity and energy metabolism. The treatment with 7,8-DHF elevated 
      the mitochondrial respiratory capacity, which emphasizes the role of BDNF-TrkB 
      signaling as mitochondrial bioenergetics stimulator. Omega-3 deficiency worsened 
      the effects of TBI on anxiety-like behavior and potentiated a reduction of 
      anxiolytic neuropeptide Y1 receptor (NPY1R). These results highlight the action 
      of metabolic preconditioning for building long-term neuronal resilience against 
      TBI incurred during adulthood. Overall, the results emphasize the interactive 
      action of metabolic and plasticity signals for supporting neurological health.
CI  - Copyright (c) 2013. Published by Elsevier B.V.
FAU - Agrawal, Rahul
AU  - Agrawal R
AD  - Department of Integrative Biology & Physiology, UCLA, Los Angeles, CA 90095, USA.
FAU - Tyagi, Ethika
AU  - Tyagi E
AD  - Department of Integrative Biology & Physiology, UCLA, Los Angeles, CA 90095, USA.
FAU - Vergnes, Laurent
AU  - Vergnes L
AD  - Department of Human Genetics, David Geffen School of Medicine, UCLA, Los Angeles, 
      CA 90095, USA.
FAU - Reue, Karen
AU  - Reue K
AD  - Department of Human Genetics, David Geffen School of Medicine, UCLA, Los Angeles, 
      CA 90095, USA.
FAU - Gomez-Pinilla, Fernando
AU  - Gomez-Pinilla F
AD  - Department of Integrative Biology & Physiology, UCLA, Los Angeles, CA 90095, USA; 
      Department of Neurosurgery, UCLA Brain Injury Research Center, Los Angeles, CA 
      90095, USA. Electronic address: fgomezpi@ucla.edu.
LA  - eng
GR  - P01 HL090553/HL/NHLBI NIH HHS/United States
GR  - S10 RR026744/RR/NCRR NIH HHS/United States
GR  - NS056413/NS/NINDS NIH HHS/United States
GR  - NS050465/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20131215
PL  - Netherlands
TA  - Biochim Biophys Acta
JT  - Biochimica et biophysica acta
JID - 0217513
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Fatty Acids, Omega-3)
RN  - 0 (Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha)
RN  - 0 (Ppargc1a protein, rat)
RN  - 0 (Transcription Factors)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Animals
MH  - Anxiety/etiology
MH  - Brain Injuries/*metabolism
MH  - Brain-Derived Neurotrophic Factor/physiology
MH  - *Energy Metabolism
MH  - Fatty Acids, Omega-3/administration & dosage
MH  - Female
MH  - *Homeostasis
MH  - Mitochondria/physiology
MH  - *Neuronal Plasticity
MH  - Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, trkB/physiology
MH  - Signal Transduction
MH  - Transcription Factors/analysis
OTO - NOTNLM
OT  - Anxiety
OT  - Brain Trauma
OT  - Metabolism
OT  - Mitochondria
OT  - Omega-3
OT  - Plasticity
EDAT- 2013/12/19 06:00
MHDA- 2014/04/24 06:00
CRDT- 2013/12/19 06:00
PHST- 2013/10/08 00:00 [received]
PHST- 2013/12/01 00:00 [revised]
PHST- 2013/12/10 00:00 [accepted]
PHST- 2013/12/19 06:00 [entrez]
PHST- 2013/12/19 06:00 [pubmed]
PHST- 2014/04/24 06:00 [medline]
AID - S0925-4439(13)00359-1 [pii]
AID - 10.1016/j.bbadis.2013.12.004 [doi]
PST - ppublish
SO  - Biochim Biophys Acta. 2014 Apr;1842(4):535-46. doi: 10.1016/j.bbadis.2013.12.004. 
      Epub 2013 Dec 15.