PMID- 2434735
OWN - NLM
STAT- MEDLINE
DCOM- 19870408
LR  - 20190724
IS  - 0160-2446 (Print)
IS  - 0160-2446 (Linking)
VI  - 8
IP  - 6
DP  - 1986 Nov-Dec
TI  - Plasma catecholamines and neuropeptide-Y as indices of sympathetic nerve activity 
      in normotensive and stroke-prone spontaneously hypertensive rats.
PG  - 1113-21
AB  - The suitability of plasma catecholamines (CAs) and neuropeptide-Y (NPY) as 
      biochemical indices of sympathetic nerve activity (SNA) has been investigated, 
      and these parameters have been compared between adult normotensive (WKY) and 
      stroke-prone spontaneously hypertensive rats (SHRSP). Plasma norepinephrine (NE), 
      epinephrine (E) and NPY were measured in venous and arterial blood samples taken 
      from conscious, unrestrained rats. Under resting conditions, both CAs were 
      significantly higher in SHRSP than in WKY; plasma E in particular was raised 
      threefold. SHRSP had higher plasma levels of NPY in arterial blood but not in 
      venous blood. Acute hydralazine-induced hypotension caused a slight rise in NPY 
      and striking increases of CAs, which were accentuated in SHRSP. Ganglion blockade 
      with pentolinium reversed these increases but the differences in basal plasma CA 
      levels between strains still persisted. Barbiturate anaesthesia had little effect 
      on plasma levels of NPY or NE, but plasma E levels were depressed, particularly 
      in SHRSP, so that the strain difference in plasma E taken from venous blood was 
      no longer apparent. The results indicate that plasma levels of CAs but not NPY 
      are useful indices of SNA in conscious rats. Comparisons between WKY and SHRSP 
      after drug treatment demonstrate a major contribution by the adrenal medulla to 
      plasma CA levels in SHRSP which, under resting conditions, may not be 
      sympathetically evoked.
FAU - Howe, P R
AU  - Howe PR
FAU - Rogers, P F
AU  - Rogers PF
FAU - Morris, M J
AU  - Morris MJ
FAU - Chalmers, J P
AU  - Chalmers JP
FAU - Smith, R M
AU  - Smith RM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Cardiovasc Pharmacol
JT  - Journal of cardiovascular pharmacology
JID - 7902492
RN  - 0 (Catecholamines)
RN  - 0 (Neuropeptide Y)
RN  - 26NAK24LS8 (Hydralazine)
SB  - IM
MH  - Anesthesia
MH  - Animals
MH  - Blood Pressure/drug effects
MH  - Catecholamines/*blood
MH  - Hydralazine/pharmacology
MH  - Hypertension/*blood
MH  - Male
MH  - Neuropeptide Y/*blood
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred WKY
MH  - Species Specificity
MH  - Sympathetic Nervous System/*physiology
EDAT- 1986/11/01 00:00
MHDA- 1986/11/01 00:01
CRDT- 1986/11/01 00:00
PHST- 1986/11/01 00:00 [pubmed]
PHST- 1986/11/01 00:01 [medline]
PHST- 1986/11/01 00:00 [entrez]
AID - 10.1097/00005344-198611000-00004 [doi]
PST - ppublish
SO  - J Cardiovasc Pharmacol. 1986 Nov-Dec;8(6):1113-21. doi: 
      10.1097/00005344-198611000-00004.