PMID- 24347931
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140624
LR  - 20211021
IS  - 0974-1208 (Print)
IS  - 1998-4766 (Electronic)
IS  - 1998-4766 (Linking)
VI  - 6
IP  - 3
DP  - 2013 Jul
TI  - A clinical appraisal of the genetic basis in unexplained male infertility.
PG  - 176-82
LID - 10.4103/0974-1208.121419 [doi]
AB  - Unexplained male infertility (UMI), the inability to reproduce despite having a 
      normal sexual history, physical exam and semen analysis, can have a genetic 
      origin. Currently, few diagnostic tools are available for detecting such genetic 
      abnormalities. Karyotyping and fluorescence in situ hybridization (FISH) are 
      respectively used for chromosomal alterations in somatic cells and sperm 
      aneuploidy assessment. Gene sequencing and mutational analysis have been 
      introduced for identifying specific mutations and polymorphisms. Other approaches 
      to the molecular evaluation of spermatozoa are under investigation, including 
      array comparative genomic hybridization and whole-genome sequencing and 
      non-coding ribonucleic acid arrays. Although treating cytogenetic abnormalities 
      and genetic aberrations is still out of reach, the integration of these novel 
      techniques may unravel hidden genetic defects in UMI. Finally, a deeper 
      understanding of the sperm epigenome might allow the development of therapies 
      based on epigenome modifications. This review focuses on the genetic basis of UMI 
      and highlights the current and future methods for the evaluation of genetic 
      defects as they relate to UMI. Review of the literature was carried out using 
      ScienceDirect, OVID, PubMed and MedLine search engines.
FAU - Esteves, Sandro C
AU  - Esteves SC
AD  - Male Infertility Sector ANDROFERT, Andrology and Human Reproduction Clinic, 
      Referral Center for Male Reproduction, Campinas, Sao Paulo, Brazil.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - India
TA  - J Hum Reprod Sci
JT  - Journal of human reproductive sciences
JID - 101473512
PMC - PMC3853873
OTO - NOTNLM
OT  - Diagnosis
OT  - epigenetics
OT  - genetics
OT  - genome
OT  - male infertility
OT  - unexplained infertility
COIS- Conflict of Interest: None declared.
EDAT- 2013/12/19 06:00
MHDA- 2013/12/19 06:01
PMCR- 2013/07/01
CRDT- 2013/12/19 06:00
PHST- 2013/09/03 00:00 [received]
PHST- 2013/09/13 00:00 [revised]
PHST- 2013/09/14 00:00 [accepted]
PHST- 2013/12/19 06:00 [entrez]
PHST- 2013/12/19 06:00 [pubmed]
PHST- 2013/12/19 06:01 [medline]
PHST- 2013/07/01 00:00 [pmc-release]
AID - JHRS-6-176 [pii]
AID - 10.4103/0974-1208.121419 [doi]
PST - ppublish
SO  - J Hum Reprod Sci. 2013 Jul;6(3):176-82. doi: 10.4103/0974-1208.121419.