PMID- 24348336
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20131218
LR  - 20211021
IS  - 1662-5102 (Print)
IS  - 1662-5102 (Electronic)
IS  - 1662-5102 (Linking)
VI  - 7
DP  - 2013
TI  - A role for the canonical nuclear factor-kappaB pathway in coupling 
      neurotrophin-induced differential survival of developing spiral ganglion neurons.
PG  - 242
LID - 10.3389/fncel.2013.00242 [doi]
LID - 242
AB  - Neurotrophins are key players of neural development by controlling cell death 
      programs. However, the signaling pathways that mediate their selective responses 
      in different populations of neurons remain unclear. In the mammalian cochlea, 
      sensory neurons differentiate perinatally into type I and II populations both 
      expressing TrkB and TrkC, which bind respectively brain-derived neurotrophic 
      factor (BDNF) and neurotrophin-3 (NT3). How these two neuronal populations 
      respond differentially to these two neurotrophins remains unknown. Here, we 
      report in rat the segregation of the nuclear factor-kappaB (NFkappaB) subunit p65 
      specifically within the type II population postnatally. Using dissociated 
      cultures of embryonic and postnatal spiral ganglion neurons, we observed a 
      specific requirement of NFkappaB for BDNF but not NT3-dependent neuronal survival 
      during a particular postnatal time window that corresponds to a period of 
      neuronal cell death and hair cell innervation refinement in the developing 
      cochlea. Consistently, postnatal p65 knockout mice showed a specific decreased 
      number in type II spiral ganglion neurons. Taken together, these results identify 
      NFkappaB as a type II neuron-specific factor that participates in the selective 
      survival effects of BDNF and NT3 signaling on developing spiral ganglion neurons.
FAU - Vandenbosch, Renaud
AU  - Vandenbosch R
AD  - Groupe Interdisciplinaire de Genoproteomique Appliquee-Neurosciences, 
      Developmental Neurobiology Unit, University of Liege Liege, Belgium.
FAU - Chocholova, Eva
AU  - Chocholova E
AD  - Groupe Interdisciplinaire de Genoproteomique Appliquee-Neurosciences, 
      Developmental Neurobiology Unit, University of Liege Liege, Belgium.
FAU - Robe, Pierre A
AU  - Robe PA
AD  - Department of Human Genetics, University of Liege Liege, Belgium ; Groupe 
      Interdisciplinaire de Genoproteomique Appliquee-Research Center, University of 
      Liege Liege, Belgium.
FAU - Wang, Yiqiao
AU  - Wang Y
AD  - Department of Neuroscience, Karolinska Institute Stockholm, Sweden.
FAU - Lambert, Cecile
AU  - Lambert C
AD  - Bone and Cartilage Research Unit, Institute of Pathology, Centre Hospitalier 
      Universitaire du Sart-Tilman Liege, Belgium.
FAU - Moonen, Gustave
AU  - Moonen G
AD  - Groupe Interdisciplinaire de Genoproteomique Appliquee-Neurosciences, 
      Developmental Neurobiology Unit, University of Liege Liege, Belgium ; Department 
      of Neurology, Centre Hospitalier Universitaire du Sart Tilman Liege, Belgium.
FAU - Lallemend, Francois
AU  - Lallemend F
AD  - Groupe Interdisciplinaire de Genoproteomique Appliquee-Neurosciences, 
      Developmental Neurobiology Unit, University of Liege Liege, Belgium ; Department 
      of Neuroscience, Karolinska Institute Stockholm, Sweden.
FAU - Malgrange, Brigitte
AU  - Malgrange B
AD  - Groupe Interdisciplinaire de Genoproteomique Appliquee-Neurosciences, 
      Developmental Neurobiology Unit, University of Liege Liege, Belgium.
FAU - Hadjab, Saida
AU  - Hadjab S
AD  - Groupe Interdisciplinaire de Genoproteomique Appliquee-Neurosciences, 
      Developmental Neurobiology Unit, University of Liege Liege, Belgium ; Department 
      of Neuroscience, Karolinska Institute Stockholm, Sweden.
LA  - eng
PT  - Journal Article
DEP - 20131128
PL  - Switzerland
TA  - Front Cell Neurosci
JT  - Frontiers in cellular neuroscience
JID - 101477935
PMC - PMC3842586
OTO - NOTNLM
OT  - NF-kappaB
OT  - cochlea
OT  - development
OT  - neuronal survival
OT  - neurotrophins
OT  - spiral ganglion neurons
EDAT- 2013/12/19 06:00
MHDA- 2013/12/19 06:01
PMCR- 2013/01/01
CRDT- 2013/12/19 06:00
PHST- 2013/07/17 00:00 [received]
PHST- 2013/11/14 00:00 [accepted]
PHST- 2013/12/19 06:00 [entrez]
PHST- 2013/12/19 06:00 [pubmed]
PHST- 2013/12/19 06:01 [medline]
PHST- 2013/01/01 00:00 [pmc-release]
AID - 10.3389/fncel.2013.00242 [doi]
PST - epublish
SO  - Front Cell Neurosci. 2013 Nov 28;7:242. doi: 10.3389/fncel.2013.00242. 
      eCollection 2013.