PMID- 24348360
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140624
LR  - 20211021
IS  - 1662-5161 (Print)
IS  - 1662-5161 (Electronic)
IS  - 1662-5161 (Linking)
VI  - 7
DP  - 2013 Nov 28
TI  - Navigating the complex path between the oxytocin receptor gene (OXTR) and 
      cooperation: an endophenotype approach.
PG  - 801
LID - 10.3389/fnhum.2013.00801 [doi]
LID - 801
AB  - Although cooperation represents a core facet of human social behavior there 
      exists considerable variability across people in terms of the tendency to 
      cooperate. One factor that may contribute to individual differences in 
      cooperation is a key gene within the oxytocin (OT) system, the OT reception gene 
      (OXTR). In this article, we aim to bridge the gap between the OXTR gene and 
      cooperation by using an endophenotype approach. We present evidence that the 
      association between the OXTR gene and cooperation may in part be due to how the 
      OXTR gene affects brain systems involved in emotion recognition, empathy/theory 
      of mind, social communication and social reward seeking. There is evidence that 
      the OXTR gene is associated with the functional anatomy of the amygdala, visual 
      cortex (VC), anterior cingulate and superior temporal gyrus (STG). However, it is 
      currently unknown how the OXTR gene may be linked to the functional anatomy of 
      other relevant brain regions that include the fusiform gyrus (FG), superior 
      temporal sulcus (STS), ventromedial prefrontal cortex (VMPFC), temporoparietal 
      junction (TPJ) and nucleus accumbens (NAcc). We conclude by highlighting 
      potential future research directions that may elucidate the path between OXTR and 
      complex behaviors such as cooperation.
FAU - Haas, Brian W
AU  - Haas BW
AD  - Department of Psychology, University of Georgia Athens, GA, USA ; 
      Interdisciplinary Neuroscience Graduate Program, University of Georgia Athens, 
      GA, USA.
FAU - Anderson, Ian W
AU  - Anderson IW
AD  - Department of Psychology, University of Georgia Athens, GA, USA.
FAU - Smith, Jessica M
AU  - Smith JM
AD  - Interdisciplinary Neuroscience Graduate Program, University of Georgia Athens, 
      GA, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20131128
PL  - Switzerland
TA  - Front Hum Neurosci
JT  - Frontiers in human neuroscience
JID - 101477954
PMC - PMC3842510
OTO - NOTNLM
OT  - OXTR
OT  - cooperation
OT  - genetics
OT  - oxytocin
OT  - social-cognition
EDAT- 2013/12/19 06:00
MHDA- 2013/12/19 06:01
PMCR- 2013/01/01
CRDT- 2013/12/19 06:00
PHST- 2013/03/01 00:00 [received]
PHST- 2013/11/04 00:00 [accepted]
PHST- 2013/12/19 06:00 [entrez]
PHST- 2013/12/19 06:00 [pubmed]
PHST- 2013/12/19 06:01 [medline]
PHST- 2013/01/01 00:00 [pmc-release]
AID - 10.3389/fnhum.2013.00801 [doi]
PST - epublish
SO  - Front Hum Neurosci. 2013 Nov 28;7:801. doi: 10.3389/fnhum.2013.00801.