PMID- 24348778
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 7
IP  - 1
DP  - 2014 Jan
TI  - Changes in monoclonal HLA-DR antigen expression in acute organophosphorus 
      pesticide-poisoned patients.
PG  - 137-140
AB  - The aim of this study was to investigate changes in human leukocyte antigen 
      (HLA)-DR expression of peripheral blood mononuclear cells (MNCs) in patients with 
      acute organophosphorus pesticide poisoning (AOPP). HLA-DR antigen expression of 
      peripheral blood MNCs was examined in 75 patients with AOPP, including 36 
      patients without multiple organ dysfunction syndrome (non-MODS) and 39 patients 
      with multiple organ dysfunction syndrome (MODS), as well as in 30 healthy 
      individuals using flow cytometry assay. The associations between HLA-DR antigen 
      expression and certain parameters were analyzed, including acute physiology and 
      chronic health evaluation II (APACHE II) score, serum cholinesterase (ChE) 
      activity, cardiac troponin I (cTnI), cardiac enzymes, and liver and kidney 
      function. The mean fluorescence intensity (MCF) of HLA-DR expression in the AOPP 
      group (21.59+/-5.36) was significantly lower than that in the control group 
      (27.85+/-4.86) (P<0.001). The MCF in the MODS group (18.17+/-4.23) was lower than 
      that in the non-MODS group (25.15+/-6.15). In addition, the MCF of the deceased 
      patients (15.29+/-3.97) was lower than that of the surviving patients (22.34+/-2.76) 
      (P<0.001). The MCF of patients with AOPP and MODS was positively correlated with 
      serum ChE (P<0.01) and negatively correlated with the APACHE II score, creatine 
      kinase isoenzyme, cTnI, lactate dehydrogenase, alanine aminotransferase, 
      aspartate aminotransferase, blood urea nitrogen and serum creatinine (P<0.05). In 
      conclusion, HLA-DR expression in patients with AOPP was significantly decreased 
      compared with that in healthy individuals; HLA-DR expression may therefore be a 
      good indicator for evaluating AOPP, MODS disease severity, immune function, 
      efficacy of prognosis and prognosis. Examination of HLA-DR antigen expression may 
      be of crucial clinical value.
FAU - Xia, Chenyun
AU  - Xia C
AD  - Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, 
      P.R. China.
FAU - Wang, Mi
AU  - Wang M
AD  - Department of Nephropathy, People's Hospital of Peking University, Beijing 
      100044, P.R. China.
FAU - Liang, Qi
AU  - Liang Q
AD  - Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, 
      P.R. China.
FAU - Yun, Ling'an
AU  - Yun L
AD  - Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, 
      P.R. China.
FAU - Kang, Housheng
AU  - Kang H
AD  - Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, 
      P.R. China.
FAU - Fan, Lei
AU  - Fan L
AD  - Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, 
      P.R. China.
FAU - Wang, Dongsheng
AU  - Wang D
AD  - Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, 
      P.R. China.
FAU - Zhang, Guoyuan
AU  - Zhang G
AD  - Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, 
      P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20131022
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC3861476
OTO - NOTNLM
OT  - acute organophosphate pesticide poisoning
OT  - human leukocyte antigen-DR
OT  - multiple organ dysfunction syndrome
EDAT- 2013/12/19 06:00
MHDA- 2013/12/19 06:01
PMCR- 2013/10/22
CRDT- 2013/12/19 06:00
PHST- 2013/05/20 00:00 [received]
PHST- 2013/10/16 00:00 [accepted]
PHST- 2013/12/19 06:00 [entrez]
PHST- 2013/12/19 06:00 [pubmed]
PHST- 2013/12/19 06:01 [medline]
PHST- 2013/10/22 00:00 [pmc-release]
AID - etm-07-01-0137 [pii]
AID - 10.3892/etm.2013.1356 [doi]
PST - ppublish
SO  - Exp Ther Med. 2014 Jan;7(1):137-140. doi: 10.3892/etm.2013.1356. Epub 2013 Oct 
      22.